Chapter 737

Very difficult,

almost impossible.

After seeing this information, the postdoctoral students of three young people immediately withdrew. After all, Xu Mang's proposal to solve the problem of replacing a DNA fragment with a target sequence is a false proposition in the world. It does exist, but it cannot be realized.

"Is it hard?" Seeing the expressions of the three men, Xu mang knew that they might think they were crazy and put forward such demands. However, these demands were just made by others. Then he said helplessly, "this is the requirement issued by the Academy of Sciences, so... Let's try our best."

All of a sudden,

without any words, the three people quietly accepted the difficulty that could not be completed. If there was not Xu mang standing in front of them, they might have left, but standing in front of them was Xu Mang, they thought that there might be a glimmer of opportunity.

"Professor Xu?"

"What kind of approach do we take?" "Is ai the same as before?" asked a postdoctoral? Using artificial intelligence to give new life to gene editing research

Xu shook his head blankly and said calmly, "I don't know... Maybe, but we should first complete the theoretical framework of the problem of replacing a DNA fragment with a target sequence, and this problem is not the only problem we need to solve, and we will encounter new problems at any time later."

And new ones?

This is...

to replace it with the target sequence problem is so difficult that it is only one of many problems.

Finally, he began to work,

however, he never thought that the so-called starting work was to do experiments repeatedly, from CRISPR – cas9 system, and only recorded the process of each failure. Xu mang was responsible for checking the process of these errors.

No way,

this is the best way for Xu mang to think of. Through the comparison of the error process, we can find the breakthrough point. Two days a day is still stable, but as time goes by, everyone's enthusiasm is gradually exhausted, just like a walking corpse.

On this day,

less than five days before the school holiday,

postdoctoral Xiao Chen came to the laboratory. Today, he was going to ask Xu mang for leave in advance. He was about to celebrate the Spring Festival. He had to go home early to avoid the peak period of Spring Festival transportation. However, when he told his ideas to two other colleagues, he found that the three had the same idea.

“？？？”

“？？？”

“？？？”

Xiao Chen said with a confused face: "do we all have to go back? What about this project? Let Professor Xu mang stay in the laboratory alone? Although he is half a devil, is he too cruel to him? "

"What about that?" Xiao Shen said with a bitter smile: "can't we not go home?"

"Yes."

"After all, it's Spring Festival. I should go back. I haven't been back for a year." "In fact, this problem can't be solved for a while. We've been working on it for a week, but we're still in the same place. We'd better relax and change our mood," he said

At this time,

Xu mang came to the laboratory slowly with a bag of fried bread and two bags of soybean milk. He saw three people sitting together chatting and asked with a smile, "have you had breakfast? I've bought a lot of fried buns. How about some of them? "

Seeing Xu Mang's arrival,

for a while, they didn't know how to speak. Finally, Xiao Chen said, "Professor Xu... I'm going to ask you for leave today. I want to go home in advance to avoid the army of Spring Festival transportation. I haven't gone back for a year..."

"Professor Xu, I also want to ask for leave."

"Me too."

Faced with the three people's request for leave, Xu mang was not surprised. He nodded with a smile: "all of them have been approved. Of course, we have to go back for the Chinese New Year. By the way...

the words fell,

Xu mang took out three red envelopes from his satchel and handed them to the three people respectively. He said seriously:" originally, I planned to give it to you later. Since you are going home today, please do it now Give you the red envelope. "

Suddenly get Xu Mang's red envelope, three people a time very surprised, but more surprised, and then, this red envelope thick has some exaggeration, even a whole ten thousand yuan.

"This..."

"Professor Xu?"

"The red envelope is too thick to be true." Xiao Chen said solemnly, "we can't accept it."

"Take it."

"I don't know how much money is in it. My wife prepared it for me." Xu mang indifferently said: "take it, close it, it's ok... Who dares to talk nonsense, let him come directly to me and confront me face to face."

Looking at the three separated people,

Xu mang returned to the empty laboratory again. Maybe this is his fate, the fate of fighting alone, sitting in the office, smoking silently, thinking about the future, thinking about how to face failure or success.

The problem of replacing a DNA fragment with a target sequence has been studied for more than a week. Wandering around in a maze, we can't find any way out at all. In the process of seeking the truth, it has been so rough, and the result is more cruel in reality.After thinking about it for a while,

Xu mang decided to go out for a walk. If he stayed in the office for a long time, his nerves would collapse.

In the campus,

Xu mang walked all the way to the school gate and saw that many students were ready to go home. However, the scene in front of him made Xu mang a little melancholy. He went to a coffee shop that had not been closed, ordered a cup of coffee for himself, and sat by a window and looked at all kinds of people on the road.

Perhaps,

on the day of birth, no one knows, but it is an unreasonable world.

Some people's dream is the star sea, some people's dream is a house, some people are born with talent, some people rely on sweat to support... Can't lose in the starting line, but some people have been standing at the end.

This is the reality, this is the reality of a huge gap, and finally accept that they are just ordinary people.

Admit your life?

However...

what Xu mang sees is hard work. It takes a lot of courage to live in this unreasonable world.

"Hello?"

"Wife?"

"I'm in the... Cafe." Xu mang received a call from Xiaoman and said with a smile: "no... everyone has gone home for the Spring Festival. I am a lonely old man left in the laboratory. What can I do? I can only sit outside and drink coffee. "

"..."

"say it and go home." Yang Xiaoman suddenly fell into meditation and seriously said: "husband... This year's new year's Eve or return to your home, and then the third day of the lunar new year back to the devil?"

"Well!"

At this time,

Yang Xiaoman squeaked and asked, "what gift should I buy?"

"No need."

"My parents just want to see you. They don't need any presents." Xu mang said calmly, "why don't you buy some jewelry and get some tea for my father?"

"Well!"

"I'll do it right away."

After drinking a cup of coffee, Xu mang returned to the laboratory in silence and began his day without clue. Until noon, Xu mang woke up from this confused state, ate a not so delicious lunch, and then began to lose his mind in the afternoon.

This day, Xu mang has been confused by this day. He really can't do anything about it. He originally wanted to solve the problem by the system, but he found that this time the system was limited and he had to rely on himself to solve it. What's more, he accidentally triggered the task and asked to solve it before the new year.

...

"horizontal trough?"

"Why... Why is there no one?"

On his way to the laboratory, Xu found that the school was empty.

Sitting on the chair in the office, he took out the experimental data of the previous three postdoctors. This is the N + 1 time for repeated comparison. Before that, Xu did not make any progress, and this time it was almost the same, but it has become a habit.

"Maybe..."

"I think I'm wrong." Xu mang frowned and took out his notebook from his bag. After connecting to the Internet, he opened the database of the Institute of Biochemistry and cell biology of the Academy of Sciences. Xu mang plans to replace DNA fragments with target sequence questions for centralized collection.

"Ah?"

"Wait a minute!"

"Why do I keep staring at the problem of replacing DNA fragments with target sequences?" Xu mang suddenly wakes up. He finds that he has too much iron in his head when replacing DNA fragments with target sequences. This problem can be bypassed completely.

An immature idea emerges. First, a DNA strand is cut off and inserted into the target sequence y. then the original sequence is cut off and another UN edited DNA strand is cut off. Finally, CRISPR system repairs the cut DNA strand.

This is Xu Mang's preliminary idea. Like CRISPR – cas9 system, cas9 is used to identify specific DNA sequences. However, cas9 has been modified to cut only one DNA strand, and then reverse enzymes conduct gene editing at the cut site under the guidance of RNA strand.

"Yes

"I feel it gradually!" Xu mang suddenly got a new life, but this feeling of new life only lasted for about ten seconds, and he was suddenly dumbfounded. If he followed this idea, it seemed that he needed a lot of research and experiment, but he could not do biological research.

Xiao man?

Xiao man studies economics and knows how to do biological experiments.

"What to do?"

"How about... Find academician Zhong?" Xu mang took out his mobile phone and dialed the number.

Toot,

rang,

Xu mang hung up directly.

Shouldn't this be the time for Xu man system 2 to play?At night,

night,

always comes quietly,

Yang Xiaoman has just thrown all his clothes into the washing machine and is going to go back to the living room to watch TV, only to find that Xu Mang, who should have collapsed on the sofa, has disappeared.

"What's the situation?"

"What about this guy?" Yang Xiaoman frowned, thinking that he seems to be struggling with the progress of scientific research recently. Has he found a solution to the problem?

He crept to the door of Xu Mang's study and opened a crack in the door. Through this tiny gap, Yang Xiaoman found Xu mang sitting in front of the computer, tapping the keyboard solemnly. After a while, he lowered his head and took up his pen. He did not know what he was calculating on the paper.

Xiaoman quietly closed the door, but with a trace of love.

This grinding villain!

......

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