Chapter 738

This day,

Institute of Biochemistry and cell biology, Chinese Academy of Sciences.

Academician Zhong was dissatisfied with the progress of the molecular biology department. However, there was no news from Xu mang. For a moment, he was a little desperate. He saw that the new year was coming soon. However, why was his heart so bad.

"Alas..."

"is the project going to drag on for a year?" Academician Zhong originally thought that finding Xu mang could quickly solve the problem of breakthrough in the field of gene editing, but in fact, it happened that he was in a dilemma.

The time to talk to Xu mang on the phone should have been ten days ago. At that time, that kind of feeble voice, I'm afraid... I was tortured by this problem.

At this time,

academician Chu, an expert in bioinformatics, came to academician Zhong's office. Seeing his helpless expression, he couldn't help but smile: "I said Lao Zhong... You've been sad for nearly three months, almost all right. It's almost time for the new year. Can you change your expression?"

"Alas..."

"I want to change it, but how?" Academician Zhong sighed: "the progress of molecular biology department is almost zero, and Xu Mang's situation is not very optimistic. I'm afraid it will be postponed indefinitely. Research funds in the next year will be greatly reduced, at least about 20% in the field of gene editing."

"No way."

"It's too big... Some people are against it." Sitting opposite academician Zhong, Lao Chu said quietly, "but you are much better than Xu mang. The collider project has been stuck all the time. Because of this project problem, Xu mang even resigned as a professor. His difficulties are much more serious than yours."

Hearing Lao Chu's words, academician Zhong said with a bitter smile: "yes, it's not a concept of difficulty."

"Say..."

"have you contacted Xu mang?" Old Chu asked curiously, "why don't you call now? I have a strong premonition that Xu mang may have completed his breakthrough in the field of gene editing. When did you connect with Xu mang before

"Ten days ago."

"Ten days ago?" Old Chu's face showed a trace of bitterness: "no ten days can be bad, now you ask... May give you an unexpected result, by the way... Hands free!"

Academician Zhong:???

What's the situation?

Why is old Chu strange today.

No way,

academician Zhong made a phone call to Xu Mang, and soon got through.

"Hello?"

"Academician Zhong?" Xu Mang's voice came out, with a trace of playfulness in his words, and said: "the new year is coming soon... I'll give you a new year's greetings in advance, and I won't go there... The distance between the magic capital and the capital is not so far."

"..."

"..."

they were helpless and seemed to be in a good mood. Should we ask them next? After all, the Chinese New Year is coming soon. It's not good to add traffic to others at this time. It's a little inhuman.

Academician Zhong hesitated and asked for progress several times, but he swallowed it back and thought about it. He gave up the plan to ask.

However,

Xu mang proposed it.

"Academician Zhong called me to ask about the progress of the project?" Xu mang said with a smile: "I have almost finished... A primary AI system has been made, and it is being tested at this stage. It is estimated that... It is fast."

“？？？”

“？？？”

Did...

come out?

Isn't that a surprise?

Academician Zhong and academician Chu looked at each other with a look of shock on each other's faces, as well as some inconceivable.

"In my idea, I bypassed the question of replacing a DNA fragment with a target sequence, directly cutting a DNA strand, and then reverse enzymes were guided by the RNA strand to edit the gene at the site." Xu said solemnly, "although it is still crispr-cas9 system, I have transformed cas9."

Bypass?

This... This idea is OK!

Academician Zhong said in a hurry: "can you talk about something more specific?"

"Yes!"

"First, a DNA strand is cut off and inserted into the target sequence y. then the original sequence is cut off, and another UN edited DNA strand is cut off. Finally, CRISPR system repairs the cut DNA strand."

"In this way, enzymes don't need to cut the DNA double strand, so researchers don't have to rely on cell DNA repair systems that they can't control to make gene editing of the cut DNA strand." Xu stopped for a moment and said seriously: "it means that with the help of a new editing system, we can develop genetic diseases related to gene mutation."

For a moment,

the two academicians were completely silent. What Xu mang said could not be done with the existing gene editing tools."Yes

"I had another idea the day before yesterday." "Its accuracy is comparable to that of my editing tool system. This technology can realize base substitution directly through chemical methods without cutting the double strand of DNA, such as changing t to a and G to C," Xu said with a smile

"CRISPR – cas9 gene editing system can't do this, but..." Xu sighed: "this method can't solve the problem of multi base, such as the translated symptoms of amaurosis idiocy, which is caused by the wrong insertion of four DNA bases in the HEXA gene."

This...

this is simply,

is it too tough?

Hearing Xu Mang's introduction, the two leaders of the Academy of sciences have been shocked to speechless and sit in their original positions.

"In a word..."

"my localization of the new system is flexible, simple and can realize multiple gene editing functions." "The system composed of a variety of enzymes, including the modified cas9 enzyme, can change, delete a single base or insert a small DNA sequence without destroying the DNA double strand," Xu said seriously

Academician Zhong took a deep breath and asked cautiously, "how long will it take Xu mang to finish it?"

"Before Chinese New Year."

"Give me another five days, when I finish the test, I will give it to you..." Xu mang said with a smile: "you can carry out simulation test through AI, modify according to the test results, and then go to the laboratory for the final test."

"In any case, it is to reduce your workload. After all, the future is an era of artificial intelligence." Xu mang said helplessly: "academician Zhong... This is the result of my best efforts. If the result is still unsatisfactory, I'm sorry... I can't do anything about it."

Not satisfied?

You're kidding!

This is obviously more than expected!

What Xu said is more advanced than any improved CRISPR – cas9 system, because it does not rely on the cell's own repair system for gene editing.

"No!"

"Professor Xu... If all this comes true, I swear... Your new system will become the most advanced genetic editing tool in the world." Academician Zhong said seriously, "I'm not joking. It's beyond any imagination."

Xu opened his mouth and whispered, "academician Zhong... I have a request. Can we strengthen the restriction in the field of gene editing in the future? I feel... A little worried that the future human beings may not be the real human beings. "

"I know what you're worried about."

"It's true that... Our binding force is not enough, including a very serious mistake that occurred not long ago." Academician Zhong's tone is a little serious: "I will put forward relevant measures recently and implement them all within a year."

"Oh..."

"that's fine." "I'll hang up first," Xu said

For a moment,

the call was interrupted,

however, the excitement was still lingering in the hearts of academicians Zhong and Chu. It was almost impossible to imagine what they had just heard. Unexpectedly, Xu mangzhen did something in this field that the whole world did not do, and he broke through the dilemma in the field of gene editing.

"Old clock..."

"what can I do?" Academician Chu chuckled bitterly: "such a genius is actually engaged in Physics... Do you say angry?"

"Alas..."

"there is still a huge gap between our researchers and the world's top." Academician Zhong said helplessly: "it's a pity... There is only one Xu Mang in the world. I really hope to have more. I can't imagine what will happen in the future."

"One Xu mang is enough... He is almost omnipotent." Academician Chu said with a smile: "if you have difficulties, find Xu mang. There is nothing wrong with this sentence."

...

at the same time,

at the same time,

in a villa far away from the magic capital,

Xu mang is sitting on the sofa, accompanying Xiaoman to watch a boring TV play. Speaking of it, this TV play is very... Very thought-provoking. It reflects the education problems of children in modern families, and also reflects the helplessness of children in the face of learning pressure.

"Husband?"

"You say... Will our children be stupid in the future?" Yang Xiaoman frowned and asked seriously: "you are a great scientist and I am a big entrepreneur. As a result, our children's grades are always the last of the whole school. Who will go to the parents' meeting after this?"

Xu Mang: (° ー)

Yes!

In case it's very skinny, who will go?

"I'm not going!"

"I'm not going to die..." Xu shook his head and said seriously: "I'm a great scientist. I want to face and skin. Anyway, I'm not going to say anything."

Yang Xiaoman is so angry. In fact, she doesn't want to lose face, but she has to go to one of them. What can I do?Finally,

under the pressure of force, Xu mang became the first person to hold the parents' meeting.

"In fact..."

"it is not necessarily the countdown, but the positive number may be the first." Xu mang gently took Xiaoman into his arms, leaned close to her ear and said, "I ask you a question, the absorption cross section of plane light waves by bound electrons in a certain potential field."

"Excuse me, if the electron is bound to the base by the potential below..."

before Xu mang finished,

Yang Xiaoman gave a vicious look and said, "go! I won't listen to me

"Haha..."

"no, right?" Xu mang said with a smile: "the problem has been found, that is, you are too stupid to drag down my intelligent and powerful gene."

Yang Xiaoman: (* ￣＾)

after a family education, Xu mang held Xiaoman in his arms and felt a little aggrieved.

However, it is certain that Xu Yang and Xu man are invincible in fighting.

...

on this day,

xuman system No.2 was completed, but the real data of the laboratory were not available.

"Hello?"

"Academician Zhong."

"It's done, but... I'd like to ask you to lead the whole team to help me verify the correctness of the AI simulation!"

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