"I'm so angry!"

"Mingming, I am so young... How did I become an aunt?" Yang Xiaoman is crazy about buying cosmetics in the online shopping mall. When she was just walking, she was hurt by a high school girl. She was much younger than her. As a result, the little girl didn't grow eyes and called her aunt.

"Oops..."

"OK!" Xu mang sat at the head of the bed, glanced at Yang Xiaoman's tablet computer, and said in horror: "you... Your shopping cart has more than one million? You're not going to empty the shopping cart today, are you? "

"What?"

"I'm not happy. I can't vent myself by shopping?" Yang Xiaoman took a look at Xu Mang and said angrily, "am I beautiful? Tell me the truth, is the skin as tight as before? Is the appearance as lovely as before? "

Sleeping trough!

This is completely crazy!

Xu mang was speechless. Unexpectedly, an aunt hurt so much. He kicked a little man who was standing at the top of his appearance to the bottom of the valley and completely hurt his self-esteem. Xiaoman has always been a beautiful girl, but one day she became an old aunt.

What is the situation?

Why is there a little bit of joy in your heart?

"What are you laughing at?" Yang Xiaoman said angrily: "say it! Am I the same as before, mother

"Well!"

"In fact, don't pay so much attention to what others think of you. Just feel beautiful." Xu mang face serious said: "good looking leather bags are the same, but interesting soul is one in a million, Xiaoman, you are the best!"

However, in the face of Xu Mang's chicken soup, Yang Xiaoman said with disdain: "if someone said that you are not handsome at all and uglier than the white cat who wrote the novel, what would you do?"

"Fart!"

"Although I, Xu Mang, have admitted that he is the second most handsome in the world, I can't give up the position of the first commander just because of my recognition." Xu mang said angrily, "don't take this metaphor in the future. My handsome is a dream that you can't touch in this life."

You...

I'm so angry!

Anger to the extreme, Yang Xiaoman went up and bit Xu Mang's shoulder, of course, dare not force, in case of bleeding, his heart will not feel good, but must bite out tooth print, let this big idiot long memory.

"Oh

"Oh, dear!"

"It hurts, it hurts... Is it necessary for me to go to..." Xu mang face innocent said: "you are the most beautiful in my heart on the line... Why care about other people's views, saying that you have too much shopping cart... Or my husband, I will help you clean up?"

Yang Xiaoman is slightly stunned. He looks at Xu mang with wide eyes. This guy is always stingy. This time, he even proposed to help himself clean up his shopping cart. There must be a trick here!

"How do you clean it up?" Yang Xiaoman asked.

"Stupid!"

"Directly choose to delete in batches." Xu mang said with a smile: "you see... Clean up your shopping cart without spending a cent. Is my husband smart or not? Were you surprised? Don't kneel. Don't kneel. If you do, kowtow. "

Yang Xiaoman: (* ~ ^)

I can't bear it,

this bastard is going too far!

"Mother, I killed your dog today!"

"Watch the fist!"

Life is like a book. Don't jump to the end to see if it's worth reading. Just savor it. You'd better jump to the last page, because each page has its own painful memories.

"Hiss!"

"I can't stand my waist." Xu mang died in bed, trying to get up, but found that his back pain to the limit, when the moment of force, as if the jack to firmly press himself on the bed, dead or alive can not move.

"Wife?"

"Wife?"

"The old witch?"

For a moment,

the door of the bedroom was opened. Yang Xiaoman stood at the door, staring at Xu mang angrily and yelling: "what did you just call me?"

"..."

"wife!" Xu mang embarrassed and not disrespectful said: "if you can help me to tell the second grandfather, I said that I had a waist sprain last night, and then go to school in a few days. I first stayed at home for a few days, and by the way, I called my mother-in-law and said that his son-in-law would like to eat fried kidney flower."

Yang Xiaoman blushed and said angrily: "this little thing always informs mom to come over... Her old man is also very busy at ordinary times, so what... You want to eat fried kidney flower, right? I come home from work and pass by the hotel and ask the chef to make you a plate. What else do you want to eat? "

"No more."

"Exercise more in the future, always flash to the waist..."For a long time,

relying on his strong willpower, Xu mang put on his clothes and trousers, washed a simple time, and quietly supported the wall to his study.

"Ah

"I'm dying... This is just beginning!" When Xu mang thinks of the miserable life that will last for 50 years in the future, he feels a trace of despair. His whole life has been destroyed. He is a little unwilling to think about it.

It's just...

solve the problem in front of you first.

Turning on the computer, Xu mang looked through the detailed information about CRISPR system, not to mention the database of the Institute of Biochemistry and cell biology of the Academy of Sciences. It was really very useful, but after reading for a long time, he did not find any useful content.

Then,

Xu mang adopted the method of starting from the problem, such as asking for the improvement of accuracy. The CRISPR – cas9 system cut off the DNA duplex at a specific site in the genome, and then relied on the cell's own repair system to repair the damage and carry out gene editing.

However...

this kind of repair system may insert or delete DNA bases at the position where the genome is cut off, which is not entirely reliable.

"Ah?"

"Is that the problem?" Looking at the data, Xu mang tilted his head and fell into meditation. In this process, it seems that researchers can't control the results of gene editing. There may be differences between cells.

On this issue,

Xu searched the relevant data and found that biologists added templates to guide genome editing in this process, but there are still some unsolvable problems.

When a specific DNA sequence is inserted into the genome, the DNA repair system in many cells tends to insert or delete single or several bases, which is particularly unreliable because a DNA fragment cannot be replaced by a target sequence.

What to do?

That's the problem. But what should we do?

At this time, Xu Mang's mind is blank. In addition to the paste, there are all kinds of eating, drinking and playing. There is not even a punctuation mark about breaking through the existing CRISPR system.

I...

may not be able to do it!

"Hello?"

"Chenxi?" Xu mang received the call from Chen Xi, and asked with a confused face, "do you want to break up again?"

"..."

"brother Xu mang... Would you like me to break up with Tianmei? And then you can stand by and watch the play? " Chen Xi was speechless and said, "I'll say hello to you. Are you free this evening? Can I arrange it for you? How about taking a shower together

"Yes, I can!" Xu mang nodded, but soon smile into a trace of sadness, helplessly said: "you little sister man that pass?"

"..."

"or forget it?" Chen Xi helplessly said: "sister man know I pull you to take a bath, I will be scolded to death by her."

"Alas..."

"this woman is too violent." Xu sighed blankly and said calmly, "no, I don't have much time. I just promised to help others solve a problem. Now my mind is blank. This problem is too difficult..."

suddenly, there is silence on the other side of the mobile phone.

"Brother Xu mang?"

"Have you heard of olliger?" Chen Xi asked cautiously: "quite positive energy."

Xu Mang:???

What?

Oreo biscuit?

Under Chen Xi's guidance, Xu mang saw the legendary Ollie to, but after reading, or a face muddled.

Perhaps...

I have completely separated from society and my world is full of scientific research.

...

a few days later,

the building of Biology Department of Fuda was restored.

because of the arrival of one person, the harmonious atmosphere here was broken. Professor Xu mang... Came back!

"Lying trough!"

"Professor Xu seems to be in the molecular biology laboratory. I don't know what he is doing... Is he ready to develop a new AI technology?" A biology student panicked and said to his friend, "that's amazing!"

"..."

"don't say that... There may be another miracle." Another student standing on the edge said, "it's a pity... It's just a pity that three postdoctoral students in molecular biology have been arranged to study with Professor Xu. What a pity

At the same time,

in the molecular biology laboratory,

three young postdoctors stood respectfully in front of Xu mang. Although the three had high prestige among the students, they felt as if they were going back to school to do practical experience with their tutors for the first time.

Nervous!Especially nervous!

Xu mang is much younger than them, but his age here is useless. He is the youngest Nobel Prize winner in Natural Science in history, directly breaking the record held by Lawrence Bragg in 1915. At that time, Lawrence Bragg was only 25 years old, and Xu was more than three years younger than him.

"Say..."

"do you know what to study this time?" Xu asked curiously.

"Break through the existing framework of gene editing." A postdoc surnamed Chen said, "Professor Xu... The three of us are fairly good in this field."

Xu mang was stunned for a moment and said with a smile: "not bad! Then it's up to you to play. This is the problem we need to solve. I've printed a few copies. You can see for yourself what you think, and we can have a discussion among the four of us. "

For a moment,

the three young postdoctoral students got the materials and looked at them. In only a dozen seconds, they were completely confused.

This...

solves the problem of replacing a DNA fragment with a target sequence?

Are you sure you can?

No way!

......

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