Chapter 1196

When Yang Rui described it to Professor Jiang and academician Zhu, he made light of it. However, in fact, he knew that the research on using bovine rhodopsin as G-protein coupled receptor was at least three CNS papers away from the current mainstream research direction.

The first top-level paper is to sequence the adrenergic receptor genes; Second, we need to sequence bovine rhodopsin; Third, we should find that the amino acid sequences of adrenergic receptor gene and G protein coupled receptor have high similarity.

The whole process, in fact, has a certain probability.

What if Kobilka didn't sequence the adrenergic receptor gene? What if no one happened to sequence bovine rhodopsin? What if no one compares the amino acid sequences of the two?

It's all a layman's problem.

These three probability questions are like asking, in the siege of heavy troops, what if no one attacks the hills ahead, what if the enemy's heavy artillery group is not destroyed, what if the time is not the same

G Protein coupled receptors fight meat wars. There are not so many. Why, Corbica didn't sequence the adrenergic receptor gene? It won't take long for someone to do it.

Maybe a year or two later, but not too long.

No one to do bovine rhodopsin sequencing how to do? It's like asking what to do if three hours of artillery preparation is not enough. If it's not enough, it will explode for another three hours!

With so many laboratories and so much money spent, they all worked in vain and didn't even leave a name. To be an adrenaline receptor gene and bovine rhodopsin laboratory is just to choose the right target and make achievements.

When there are more soldiers charging, there will always be survivors. It's not that the enemy's machine gun sweeps slowly, nor that you have special skills of hiding guns. It's that there are enough people blocking the holes on your own side, and your dog's life is big enough.

Of course, Yang Rui is not going to make cannon fodder.

That's why he sacrificed bovine rhodopsin.

This is a secret that Europe and America have just discovered.

That is to say, the scholars who are quick to read the literature just saw it.

If Yang Rui didn't have a definite aim, he might not be able to see this information for one or two years.

In one or two years, I have been very nervous about other scientific research projects. In terms of GPCR, I almost give up completely.

This is also a difficult part for scholars in the third world countries to do scientific research. If they are in the United States or Europe, especially in areas where a project is well done, the flow of information is much better. There are more exchanges among scholars in different regions. Although they are not updated in real time, they will not be too slow.

Especially compared with the laboratories in backward areas and countries, the time difference is decisive.

If another domestic laboratory finds that it has lagged behind the international mainstream scientific research achievements for two years or a year, will it still participate in such fierce scientific research competition? Most will choose to retreat.

After all, limited funds can not be so wasted.

Also closely related to funding is the time and timing of publication.

In terms of national and regional biases, European laboratories are the most capable of holding back achievements. There are many laboratories that have been grinding their swords for ten years, and Japanese laboratories are more capable of holding back achievements. They originally have a tendency of domestic exchanges, and the independence and authority of scientific research personnel can be relatively guaranteed, so they have been holding back for three to five years or even seven to eight years, It's not too much trouble.

In contrast, laboratories in the United States can not hold back. Sometimes, for the sake of funding, laboratories can't wait to publish their results.

For example, the relationship between bovine rhodopsin and adrenergic receptor gene, if not published, might be one or two years ahead of other laboratories - of course, one or two months.

It also depends on the requirements of the laboratory for the results.

If the goal is only to publish papers of CNS level, then the relationship between the two is appropriate enough. If the goal is achieved, it is natural to publish papers without hesitation.

However, if the target is a Nobel Prize grade achievement, even if it is a risk, it will have to wait until it is published. The advantages of more funds, wide sources and less restrictions are usually reflected in this.

In reality, the publication of the relationship between bovine rhodopsin and adrenergic receptor gene also represents a new field of G protein coupled receptor research.

Most of the laboratories have entered the same starting line again.

This is the cruelty of scientific research competition like meat grinder. No matter how deep your previous efforts are, as long as one person has published the results earlier, everyone has to start again.However, Su xiankai and others obviously have not yet felt the cruelty of scientific research competition, especially the cruelty of the world's top scientific research competition.

A few of them look at the literature with a smile, and throw two little farts to Yang Rui as encouragement.

Xu Zhengping, who is the oldest, also looks at the three with an optimistic smile. He is not ready to participate in the project, but it does not hinder his expectations of the project.

Only when the ion channel laboratory develops well, can the team in the laboratory live well, which has been proved for a long time.

Yang Rui won't beat them any more. He made them happy for a while and said, "now that the goal is clear, we will follow the direction that our predecessors have developed. The first step is to extract bovine rhodopsin. Who will do it? "

Three people look at each other, Su xiankai said: "I'll be a striker."

"It's up to you. I want a lot of bovine rhodopsin, and it must be clean and clean."

"Leave it to me." Although Su xiankai had some pressure, he agreed. It can't be guaranteed 100% either. We can only say that we should try our best to do it.

Yang Rui also confirmed the beginning of the project.

As the project leader, his instructions can be completed at this stage. After that, Su xiankai needs to consider how to extract bovine rhodopsin.

It's like a siege. Yang Rui wants to capture a fortress in the forward position. He doesn't need to describe the tactics of attacking and killing the fortress in detail. That's the responsibility of the front-line commander.

Su xiankai is the current front-line commander, and he doesn't have to fight independently. The selected research dogs in one room are used to charge him. Only when it comes to the difficult point, the key point, or the front is really unable to attack, can su xiankai himself come forward.

As for the work of fan Zhenlong and Wang Sisheng, Yang Rui thought a little and said, "now you can accompany me to read the literature, and then do several groups of repeated experiments. You can choose several kinds of G protein purification, such as GT, GS, GI and so on."

Fan Zhenlong and Wang Sisheng opened their mouths and finally had no choice but to nod their heads. They put their ambition in their hearts and began to practice basic skills.

The ion channel Laboratory of Peking University is still not a world-class laboratory. It is not only the lack of funds and equipment, but also the lack of accumulated scientific research foundation.

Fan Zhenlong and Wang Sisheng had not done G protein purification before. In this battlefield, they are equivalent to the front-line commanders who have not carried out siege war. They spend precious money and time and are helpless choices.

In fact, Yang Rui himself has never done G-protein purification, and the complexity of this work has exceeded the scope that master students or ordinary doctoral students can master. However, Yang Rui has now transcended the role of front-line commander, but in the position of campaign commander, Yang Rui has rich experience.

Even if it was a mincing battle, Yang Rui was not at all false.

600 With a total funding of US $10000, there are three active calves with great potential, and another three calves have not been used for reserve service. Yang Rui has a chance to fight in Taierzhuang.

In the end of all bloody battles, the competition is all about perseverance and willpower. I think the team that can see the dawn always has to take advantage of it.