Chapter 734

Looking at Xu Mang, looking at the water fruit basket in his hand, the original sympathy for him instantly disappeared, thinking about what he usually did, the anger in his heart.

The second grandfather said angrily, "Xu mang... I told you last night, don't be late... Why are you still late for me and let academician Zhong wait so long, can you have a long memory in the future? Hao Lai is also a great scientist. How come there is no concept of time? "

"Gee..."

"I don't want to." Xu Mang, with a bitter face, said: "as soon as I closed my eyes and opened my eyes, I found that I was late... Second grandfather, I really don't blame me. Besides, I just returned home, and the time difference has not yet returned. It should have happened like this."

"..."

in the face of Xu Mang's various reasons, the second grandfather didn't want to pursue him too much. After all, things were the focus.

"This is academician Zhong, director of the Institute of Biochemistry and cell biology, Chinese Academy of Sciences." The second grandfather looked at academician Zhong, and then said, "this is Xu mang. He doesn't have a proper shape every day."

Academician Zhong felt that the relationship between his old friend and Xu mang seemed to be much more reliable than he had imagined. He suddenly felt relieved and said with a smile, "Professor Xu mang... I have heard a lot about your deeds when I first met him."

"It's all a little fuss." Xu mang said with a smile: "academician Zhong... Let's go straight to the topic. What do you want to do with me?"

"We want to use your xuman system to help predict the three-dimensional structure of proteins from amino acid sequences." "The second is about the research in the field of gene editing. We hope you can find a new system to control DNA changes more accurately," Zhong said

Xu Mang:???

What?

New... New system?

Hearing what academician Zhong said, Xu mang looked at him in a daze and said, "I remember... The most popular gene editing system is CRISPR – cas9. This system was born more than ten years ago, so... This needs a new one?"

"Yes

"In fact, CRISPR – cas9 gene editing system has great defects. It is not so smart and often makes mistakes." "We need to find new gene editing technology to make up for CRISPR – cas9. As far as I know... No one in the world is studying this."

Xu mang did not speak. He quietly looked at academician Zhong and developed a new gene editing system. This is not an ordinary difficulty. At present, crispr-cas9 is the most perfect form. In fact, CRISPR is a repetitive sequence in the genome of prokaryotes, and an immune weapon produced by the struggle between bacteria and viruses.

In short, viruses can integrate their genes into bacteria, and use bacterial cell tools to serve their own gene replication. In order to eliminate the foreign invasion genes of viruses, bacteria have evolved crispr-cas9 system.

Using this system, bacteria can quietly cut the virus gene from its own genome, that is, crispr-cas9 gene editing technology is the technology of specific DNA modification of targeted genes.

"Do you have any requirements?" Xu asked.

"Yes!"

"Reduce the risk of miss." Academician Zhong said: "the new system needs higher security than crispr-cas9 system. The so-called security is accuracy. Only by greatly reducing the miss probability can we obtain greater security."

Xu mang gave a bitter smile and said helplessly: "the difficulty is not ordinary. Crispr-cas9 system is recognized as the best gene editing technology in the world. It is cheap and easy to use. Relatively speaking, it is very accurate. If you suddenly want to pursue higher accuracy, you will lose other characteristics."

"For example..."

"the new system will be particularly expensive." "Unless artificial intelligence is used, the computer is used to simulate the experiment first, and then the experiment is carried out according to the yield rate. However, this requires a large amount of data accumulation. I don't have such data," Xu said

At this time,

academician Zhong showed a smile: "Professor Xu Mang, you don't need to worry about the data. We have a very complete database, which can be disclosed to you, and you can use the database at will."

I'm...

well prepared!

At the same time, Xu is worried that the new technology will be subverted by the new technology in the 21st century.

"What's wrong with Professor Xu mang?" When academician Zhong saw Xu Mang's appearance of hesitation, he quickly asked, "is there any problem? If there is any problem, you can raise it in person, and we can discuss it now."

"No... nothing." Xu mang helplessly said: "can you give me a few days to think about it?""Good!"

"I know what you're worried about." Academician Zhong nodded and seriously said: "Professor Xu mang... Gene editing technology is not as terrible as you think. In fact, gene editing technology is the most promising technology to cure HIV, heart disease and cancer."

Xu mang said with a wry smile: "I know that... I'm engaged in theoretical physics, and it's easy to subvert the world pattern, such as the mass energy equation... Academician Zhong, don't worry. I'm not that old-fashioned person, but I think I may not succeed."

Academician Zhong did not speak. The more this time, the less pressure he could give Xu mang.

"Say..."

"if I accept, where is the workplace?" Xu mang curiously asked: "should not go to the capital city?"

"No need."

"I think the building of Biology Department of Fuda is very good. It has very complete supporting facilities and does not need to come to Beijing." Said academician Zhong.

"Oh..."

"I'll leave first and give you a reply in a few days."

As the words fell,

Xu mang left the headmaster's office with the fruit basket he had just brought. In the face of this situation, the second grandfather was not surprised, but academician Zhong was confused. Is this fruit feeling bought by himself?

...

Xu mang collapsed on the sofa, thinking about the new system in the field of gene editing. The new system is not likely, and the difficulty is not so much as sporadic. In most cases, it should be optimized on CRISPR system.

However...

the difficulty is not so great!

CRISPR system has been a game changer in the field of biological science. This technology can discover, remove and replace specific parts of DNA through specially programmed enzymes of cas9. Moreover, it is very cheap, simple and powerful.

"Can we break through?" After all, CRISPR technology was discovered in the early 1990s, and seven years later, it became the most popular gene editing tool in the fields of human biology, agriculture and microbiology.

but...

has a little bit of Xu Yu to make complaints about it, and the United States is so shameless that she secretly obtained the first patent authorization of CRISPR, which means that CRISPR technology may be illegal.

Finally, he stayed up until five o'clock in the afternoon.

when Yang Xiaoman came home from work, he saw Xu mang lying on the sofa motionless. He was not surprised at his husband's paralysis. He came to his side and asked curiously, "you shouldn't have been lying on the sofa for a whole day?"

"No

"Half a day..." Xu mang said with a smile: "Xiaoman... I went to see my second grandfather in the morning. He introduced a person to me, academician Zhong, who is in charge of the Institute of Biochemistry and cell biology of the Academy of Sciences."

Yang Xiaoman frowned and asked calmly, "are you looking for help again?"

"Well!"

"But I'd like to challenge it, too." "This is about the research direction in the field of gene editing, looking for a new editing tool system better than the existing CRISPR system," Xu said seriously

Hearing Xu Mang's words, Yang Xiaoman's face is full of confusion, and he can't understand what he's talking about. This guy's field is more and more broad, and they all start to involve in the field of gene editing...

"Alas?"

"Big fool?"

"Are you in physics or not?" Yang Xiaoman sat beside Xu Mang and asked curiously, "I find that your branch of study is getting more and more serious. You are a theoretical physicist. Can you do your job well?"

"Alas..."

"those who can do more work." Xu mang said with a smile: "is this truth?"

"Fool!"

Yang Xiaoman gave a white eye and asked calmly, "what do you want to eat at night? I'll do it for you? Or braised pork? How about steamed bass

"Whatever."

"As long as you make it, I love it." Xu mang casually said a word, the result is such an absent-minded words, let Yang Xiaoman run into the kitchen, even the thick smoke can not stop Xu mang cooking.

The next day,

Xu was lying in bed. After a night's thinking, Xu decided to make a contribution to the field of gene editing and try to open up new possibilities. However, he probably made some changes in CRISPR system.

"Hello?"

"Second grandfather..." Xu mang said with a smile: "guess what I want to do?"

"..."

"what do you want to do?" The second grandfather said angrily, "how are you thinking about it?"

"Almost."

"I'm going to try it." "It's a very interesting challenge, and I like challenges, otherwise I won't marry Xiaoman," Xu said seriouslyThe second grandfather's tone suddenly became a little serious and said to Xu Mang, "Xu mang... Are you sure you can? This is not a trifle. Once something goes wrong, the consequences will be unimaginable. We should not consider it any more? "

"No more!"

"I've thought about it." "Accept the challenge," Xu said

Then,

they talked about the trivial matters of life, and then they hung up in a hurry.

The second grandfather took the phone and called his old friend academician Zhong in a hurry. He said it was the same as Xu mang. He got off the plane early in the morning and went back in the evening.

"Hello?"

"Old clock!"

"Xu mang agreed." The second grandfather said, "talk to him about the next thing."

......

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