Chapter 174：

After Zhao Depei hung up the phone, the whole person was dumbfounded. He could understand every word Li Zheng said, but when they were connected together, how could he not understand?

What is it? It is still possible to leave a place for China. If you are watching a movie in a cinema, you can still reserve a place for people.

What other experiments, and what experiments have produced results that can stop the debate in the American scientific community, and greatly promote the advancement of the Human Genome Project? Why didn't he hear anything about it?

"President Zhao...President Zhao?" Sun Bin said cautiously. He felt uncomfortable in his heart. He was only halfway through talking with Professor Li. Let's say Professor Li, each of them can have a separate signature. One SCI paper!

That's an SCI paper. Now that the SCI papers published on Huaqing campus can be counted by the index, he can already imagine that after he published his paper, his classmates looked envious and hated.

It's just that this achievement is related to patents. He still can't figure out what can be written and what can't. President Zhao, you just removed your hand from the phone.

"Huh?" Zhao Depei suddenly recovered from his thoughts. He saw Sun Bin who was looking at him carefully and pursed his mouth. He should be rational, how should he repeat Li Zheng's words to him? Chen Anbang and those old predecessors of the Chinese biosphere.

"Do things well." Zhao Depei patted Sun Bin on the shoulder, and walked out of the laboratory quickly with Sun Bin's puzzled expression. What he has to do now is to first write the so-called leave note with the reason for asking for leave. find out!

Meng Jie and Lu Xueke walked to Sun Bin.

"School...principal, no...it's okay." After entering the ninth laboratory, Meng Jie became more confident because of his ability in biological research, and even talked more.

"It's okay, what can the principal do! Sun Bin, did Professor Li just let us write the paper by ourselves?" He Lu Xueke stared at Sun Bin brightly.

Sun Bin glanced at him, "The ears are really sharp. That's right, the professor means that. This infinite organ storage project is called one of the tickets for the future medical industry by the Western media, and the attention is already high. Overall Project papers must be available in top international journals such as Science and Cell. Although we are only responsible for a small part of the experiment, this small part is written as an academic paper, and the threshold for SCI papers can still be reached."

Lu Keke let out a cheer, "I feel like I am dreaming!"

On the other side, Zhao Depei returned to the office, rummaged through the cabinets, and finally found the leave slip that Li Zheng said.

Leave person: Li Zheng

Leave date: May 25, 1986 to June 18, 1986

Reason for asking for leave: To attend a biology conference in Long Island, New York

Go to Long Island, New York for a biology conference? !

The Cold Spring Harbor Laboratory is indeed on Long Island, New York. Yes, the experts of the Human Genome Project will meet and say that there is nothing wrong with the biology meeting! But can't you write more clearly! !

Zhao Depei clutched his chest and almost spewed out a mouthful of old blood.

"Little Chen, come here." He called Chen An's help.

When Chen An's help knocked on the door and came in, Zhao Depei was still in a daze with the leave slip.

"principal."

"Well, sit down." Zhao Depei said, and passed the slip in his hand to Chen Anbang. "Look, this is the slip used by Li Zheng to ask me for leave after the Huaqing Prize establishment ceremony."

Chen An was at a loss for help. He was so busy these days. Meng Lao left. As a disciple of Meng Lao, he received the human resources in front of Meng Lao. The Human Genome Project is like a pot of boiling oil. The water inside made the entire Chinese biological community agitated. He has recently been busy using the contacts in front of Meng Lao to make the Chinese biological community have its own voice internationally.

At this time, Zhao Depei asked him to see the leave slip?

Chen Angang is a good-tempered, Zhao Depei let him watch, he just watched. From this look, he saw that the doorway was coming, the Long Island Biology Conference in early June.

"Human Genome Expert Meeting?!" Chen Anbang stood up abruptly, his voice slightly high because of surprise.

"Well, that's right." Chen Angang saw it at a glance, Zhao Depei muttered in his heart, it's not to blame him, he is not in the biological circle, he has no sensitivity.

"Li Zheng participated in the Human Genome Expert Meeting? What did he say, did you tell him what we mean?" Chen Angang looked at Zhao Depei nervously, holding the fake slip tightly in his hand, grabbing its corners Extremely wrinkled.

"He, he said it's not a good time for China to participate in the Human Genome Project..." Zhao Depei repeated Li Zheng's words to Chen Angang.

After listening to Chen An, he was speechless for a long time. After a long time, he stood up and said, "This is not something I can decide. I want to discuss it with them."

Not to mention the fact that the biologists in China had been arguing for half a month after hearing this news, Li Zheng and Ruiz finally found a suspected target one month later.

EGFR

"The mutations are concentrated in exons 18-21 of the EGFR kinase region. The main mutations in the exon sequence of EGFR are 18 mutations G719, etc.; 19 deletions 15BP, 19BP, 12BP, 9BP; 20, T790M insertions; 21 mutations L85SR, etc. In 500 comparison experiments, mutation rates of 18, 19, 20, 21 were 5%, 45%, 5%, and 45%, respectively. The report is complete!" Richard said loudly.

Ruiz quickly grabbed the data analysis report in Richard's hands, "Li, I have a hunch, this must be what we are looking for!" He said excitedly.

Li Zheng certainly knew that EGRF was the target they wanted to find.

The choice of this target was carefully considered by Li Zheng. He is one of the most obvious and most easily found targets under current conditions. At the same time, this mutation is common in Asians and non-smokers, and Asian patients are as high as 60%, this is his most important purpose for starting this project first.

"Obviously, the deletion of exon 19 and the mutation of exon 21, L858R, are the two most common EGFR mutation phenomena. We are responsible for one of them. We meet every two days and share information, can we?" Li Zheng Shen Sheng Said.

Ruiz nodded vigorously, "Okay, my friend, let's start right away!"

After finding the target and studying the corresponding inhibitor, there will be a direction. Both are experts in anti-tumor drug research. Ruiz has studied lung cancer drugs for half a lifetime, and Li Zheng is standing on the shoulders of giants.

In early 1987, the U.S. Department of Energy and the National Academy of Medicine allocated $550 for the "Human Genome Project" as start-up funds, and announced the start of preparations for the laboratory.

On the second day after the U.S. Department of Energy and the National Research Institute announced this decision, Ruiz’s type 1 human epidermal growth factor receptor passed difficult biological experiments and officially entered the clinical stage!

"I got in touch with the State Hospital. In just one week, 120 patients have signed up. They are all patients with advanced lung cancer, and many of them can no longer go to the ground." Ruiz handed the registration materials to Li Zheng.

The two have worked together for half a year, and there has been a certain tacit understanding. Li Zheng turned a little bit and said, "Choose sixty. According to the severity of the illness, there are three steps for clinical comparison."

After the clinical results of advanced patients come out, decide whether to conduct clinical trials for mid-term or even early patients.

"Well, good." Ruiz nodded.

He put down the information in his hand with a tangled look on his face. He watched Li Zheng hesitated to speak, and finally couldn't help but ask.

"Li, have you participated in the whole process of drug clinical practice? I mean not only clinical data analysis, but field participation."

Participate in clinical medicine throughout the process? It seems really not.

He deliberately asked Indian manufacturers to do human clinical work during the time of paminerazine. In the case of taxane, his nerves were tight every day because of Doman’s battle. In addition to paying attention to the clinical data of the drug, he also scored time and time. The Dorman army was intriguing and had no time to participate in the whole process.

He participated in the human clinical medicine most frequently, which was probably the clinical medicine of carbapenem antibiotics, because at that time there was only one drug experimenter, his respected teacher.

As for the previous life, third-party outsourcing has developed very well, and drug researchers only need to check it occasionally. Except for special circumstances, there is no need to participate in the whole process.

Seeing Li Zheng's silence, Ruiz understood his answer, "Li, you are amazing, your academic level is very high, especially the experimental ideas, the logic is clear and the direction is clear, and you are an amazing scientist. But you are still young after all. If you can't stand the next clinical trial, please feel free to tell me that we are friends." Ruiz said solemnly.

Li Zheng didn't understand what Ruiz meant, but as the project team entered the state hospital and looked at the patients lying on the bed that almost didn't look like a living person, Li Zheng couldn't help but understand.

However, in his opinion, Ruiz really underestimated him, as a biopharmaceutical person, this is something that must be experienced.

"Professor Ruiz, Professor Li, and sixty applicants are here. They and their families have signed a drug clinical agreement. This is their case." The doctor at the state hospital handed a stack of cases to the two. .

Ruiz nodded, "I see."

Zhouli Hospital opened an entire floor as a clinical experiment base for this drug, with one room for every two patients. Sixty patients are divided into three steps according to their condition, and the best can stand up and walk for a while by themselves.

The middle one can walk for a while with the help of others.

The worst was lying on the hospital bed. I heard that it hurts even after touching it.