Chapter 1335

"Eh, crystal structure diagram?" Marjorie, a professor of biology at Caroline medical school, is not sensitive to words like G-protein-coupled receptors.

The most important thing that professors at Caroline medical school do is to read literature, especially the literature of scholars who are eligible for Nobel Prize.

For them, the Nobel Prize is an advantage as well as a burden.

The advantage is that Caroline medical college has got a lot of funds, and high-end scholars from abroad pay attention to it, while the burden is brought about by continuous reading literature.

Professors at Caroline Medical College and ordinary scholars read literature in different ways. Normal people read literature only according to their own needs. For example, if Yang Rui wants to read literature, he basically focuses on G-protein coupled receptor, PCR, gene, genetics and other fields. In a word, he reads what he needs. In other fields, he usually only reads what he needs. He can read a few CNS articles at most, Just know.

The professors of Caroline medical college can't read the literature in this way. They have to read the papers at the CNS level. Whether they are in their own field or not, they have to read them, especially the scholars who may win the Nobel Prize and the fields that may win the Nobel Prize.

One's time is limited, especially for scholars.

Nowadays, there are three or five laboratories in the slightly popular fields. The professors of Caroline Medical College spend most of their time reading the literature that has nothing to do with their own research, and the investment in scientific research itself can be imagined.

For Marjorie, he is getting tired of being a professor at Caroline medical school, but the foundation laid over the years is still there.

Hearing the words "G protein coupled receptor" and "crystal structure diagram", he was the first to wake up and quickly went to the laboratory.

To tell the truth, if it wasn't for Yang Rui, he would not believe it.

As a professor of biology at Caroline Medical College, Marjorie's most basic ability is to judge how long an academic direction can see the dawn and the results.

Of course, such a judgment is certainly inaccurate, but there is also a certain range.

Yang Rui's ion channel laboratory has just finished the clear composition of G protein coupled receptor - just a few months for Wang's scientific research achievements - Marjorie believes that the basic time to get the crystal structure diagram should be more than three years, less than two years.

Such a judgment is not a joke. Whether a laboratory wants to spend tens of millions of dollars to join in such a competition is often decided according to such a judgment

It is expected that the crystal structure of GPCR will be revealed in the next two to five years, We are likely to complete the project in the next two to four years. If we join the relevant competition, we can consider joining the competition.

The ion channel Laboratory of Peking University has completed the crystal structure of GPCR in a few months, which means that other laboratories participating in this project all over the world are at a great loss.

At the same time, it also means that the resources of the whole society have been greatly saved.

However, Marjorie was not concerned about the savings. He was nervous when he thought of the laboratory that was working on the relevant project.

Other people's reaction was slower, but they kept opening their eyes and asked, "do you have a clear crystal structure? So fast? "

"We actually completed the relevant research a few months ago, but it took a long time to repeat the experiment." Yang Rui said as he let them into the laboratory.

In fact, there are not many repeated experiments in a few months, and some verification experiments take a lot of time, even in a few years.

However, Yang Rui's words fall in the ears of those who want to, but they are as shocking as thunder.

A few months ago, we started to do repeated experiments. When did we get the results?

In recent months, many laboratories around the world are working in vain?

Marjorie was cruel when he thought about it.

However, the world of scientific research is so cruel that those who feel cruel die in the boundless competition, and those who survive can only insist.

"I'll see what you've done." Marjorie offered.

Yang Rui said with a smile, "what you see now is the result of repeated experiments. In addition, our paper has also been written."

The paper is the experimental record after sorting and sublimation, which is naturally the most suitable for reading.

Marjorie didn't talk much. He took it and read it quickly.

Behind him, Lancelot, also from Katherine medical school, slowly took a thick paper and read it quietly.It takes a lot of time to read such papers. Generally speaking, Marjorie is used to skipping.

But this time, he was a little reluctant.

It's a king level research project.

How wasteful it is not to read the papers of Wang level scientific research projects carefully.

Yang Rui was not in a hurry. He called for someone to make tea for them and sat down on the side.

After a few cups of tea, Marjorie finally raised his head and said, "director Yang, can we have a chat with the researcher of specific operation?"

"Of course." Yang Rui responds to every request.

Today is to show off skills, but he stood up and hesitated for a while, shouting: "Gu Qiang, how do you remember there?"

"I'm done." Gu Qiang answered in a low voice.

"Come here, Su xiankai, fan Zhenlong... You all come here, too." Yang Rui called several names in succession.

"I think there is the name of researcher Gu Qiang in the paper." Ma Qiaoli became accustomed to nature and began to trace the experimenters directly. He asked, "researcher Gu Qiang, would you like to introduce the experimental process?"

Gu Qiang obediently said: "I am in the presence of detergent conditions, the formation of complex? We named this complex args complex. After testing, I found that it can effectively couple in the phospholipid bilayer... "

"Wait, it's necessary to use detergent. Why do you want to form complex in the presence of detergent?" Marjorie had doubts in his first sentence.

Gu Qiang looked at Yang Rui. He didn't get the answer. He shrugged his shoulders and said, "to ensure the purity of G protein, we must use detergent. If we want a pure complex, we can only do it in the presence of detergent."

"Even if the coupling efficiency is greatly reduced?"

"Of course." Gu Qiang also studied this problem at the beginning.

However, machouli read more literature than Gu Qiang, and immediately asked, "haven't you considered another way? For example, instead of using detergent, we use physical or other methods to ensure the purity of G protein. I see that many laboratories are trying to do this. How do you make your judgment? "

Gu Qiang opened his mouth, but he didn't know how to answer.

He never thought about it.

Yang Rui's experimental scheme is to synthesize in the presence of detergent. Gu Qiang's theoretical system is weak, and he has not considered to bypass this point.

Of course, his experiment was done too fast, and he soon broke through the difficulty.

However, Marjorie's question is also very typical. Gu Qiang thought for a moment and said honestly, "this was my task at that time."

"Do you mean Mr. Yang Rui arranged your plan?"

"Yes."

Marjorie naturally turned his eyes to Yang Rui and asked, "Mr. Yang Rui, how did you think about it at that time?"

"I didn't think about it."

"Yes?"

"I've arranged for others to try other solutions." Yang Rui said calmly: "our investment in G protein coupled receptor is relatively large."

Marjorie understood immediately and said, "how many groups are you trying?"

"Of course. Su xiankai and fan Zhenlong were in different groups at that time. " Yang Rui replied in the most concise way.

That's how it was.

As the person in charge of the laboratory, Yang Rui put forward a plan to arrange different researchers for verification, which is the most basic laboratory operation plan.

It's like Yang Rui leading a March. When he encounters a fork in the road, he can decide whether to go or not according to experience and theory, but he can also send people to explore directly.

Gu Qiang fortunately found the right direction, that's all.

In a few simple words, Marjorie knew.

He asked Gu Qiang a few more questions and slowly turned the topic to Yang Rui.

Academic achievements are attributed to IQ and distributed according to IQ. Hard work itself is worthless.

Yang Rui had questions and answers, and soon established a corresponding image in people's hearts.

With the deepening of the problem, some scholars began to keep up with the dialogue between Marjorie and Yang Rui, and most of them began to focus on the project itself.

"The ion channel Laboratory of Peking University has analyzed the crystal structure of GPCR."

"Yang Rui's research is advancing very fast.""Unbelievable."

A few people's whispers gradually turned into a group of people's discussion.

It's just that it's so amazing that everyone's questions are overlapping.

Marjorie asked questions of his own, no matter what other people thought. From his point of view, understanding Yang Rui has become a necessary lesson.

Wang Qi, the representative of G protein coupled receptor, was broken through two difficulties by Yang Rui. As long as Marjorie thought about the sensation that the news would cause, he had to be more careful.

But then, in Marjorie's mind, the scene in the backyard suddenly appeared.

"Mr. Yang Rui, I remember that we talked about three-dimensional structure before? Is it the three-dimensional structure of GPCR? Are you involved in it? " As soon as Marjorie spoke, it was quiet.

The scholars on the scene seemed to be reminded, and the expression of looking at Yang Rui was also wrong.

Think about it. If the repeated experiments of crystal structure were started a few months ago, it means that the main projects were finished a few months ago. For such a long time, the ion channel Laboratory of Peking University can't only do repeated experiments without doing new research.

So, new research

Is the new research the three-dimensional structure of GPCR?

A group of biologists looked up at the tall Yang Rui, inexplicably looking up.