Chapter 793

The number of candidate compounds is shrinking day by day.

From the initial 30 species, to more than 20 species, and then to more than 10 species, until the remaining 13 compounds, the reduction rate was reduced.

The main reason why the compounds were eliminated in the early stage was that there were serious reactions in animal experiments. In fact, the application rules of new drugs in different countries are similar. If there are serious reactions in animal experiments, they are not allowed to enter clinical trials, which means that a compound has been eliminated.

This is a one vote veto system, but from the perspective of pharmaceutical companies, it is the easiest part.

Because compounds that have been rejected will not incur additional costs.

On the contrary, the remaining 13 compounds, in the process of further animal experiments, have to constantly generate costs.

It's very appropriate to describe this process by spending money like running water.

Batch after batch of mice, rats and pigeons were orally exposed to iron, and then the candidate compounds were taken separately for various tests.

The cost of chemicals and instruments alone is more than 10000 yuan per day.

Huang Mao and others did not personally participate in the study of the drug group, but when they watched, they were also frightened.

Seeing that it took them a week to reduce the number of candidate compounds from 13 to 12, Huang Mao couldn't help asking, "isn't it going to take a year for this kind of progress in animal experiments?"

Because grace was here and Huang Mao was speaking English, the former immediately replied, "it's normal to do animal experiments for a year."

Huang Mao calculated that the average cost of research is more than 10000 yuan per day. What is the cost of doing animal experiments for one year? It's definitely over 4 million yuan!

Although we have known for a long time that it costs money to develop new drugs, the feeling of money flowing away from our own eyes is even stronger.

Huang Mao couldn't help saying, "we Huarui have always exceeded the average speed in experiments, and you can't really do it for a year."

Grace tilted her head for a moment, straightened up and stretched out. After showing a good figure, she said: "in the world, there are ten pharmacists and two or three biologists participating in the development of new drugs on average... Now we have, I'll calculate, I'm a pharmacist, Yang Rui and Wang Xiaoyun, so you're right, We can't really do it for one year, and we are more likely to do it for five years. "

Huang Mao's mind of wanting to vomit trough can make complaints about the whole lab: "are you not worried?"

For a long time, Huang Mao held out such a sentence.

"It's nothing to do with me that the laboratory can't afford to hire a pharmaceutical chemist."

"If you wait five years, don't you waste five years too?" Huang Mao didn't understand any more.

"No, five years from now, there will not be other pharmaceutical companies that will do ferroketone. Moreover, since we have started animal experiments, we must complete them. Otherwise, we will be irresponsible to other pharmaceutical companies and thalassemia patients." Grace's mind circuit is very strange.

Huang Mao did not respond for a long time and asked, "why?"

"You mean..."

"The irresponsible part."

"Grace means that if we stop our animal experiments halfway through, other pharmaceutical companies may think that our animal experiments are in such a bad situation that they completely give up the deferonone project." Yang Rui listened to their conversation and said, "we are in a good state at present. No pharmaceutical company will give up the project at this stage. Therefore, unless we encounter other force majeure, the animal experiment will certainly be completed. If it is not completed, other companies and even the FDA will consider this situation. In case of litigation, The lawyers will certainly find out. "

Huang Mao understood and changed it to Chinese this time. He asked, "is it good to finish it?"

"The projects that have passed animal experiments can already be sold at a good price."

"How do you sell it?"

"There is a special market." In fact, Yang Rui is not very clear. Where did he have the opportunity to play games like mergers and acquisitions before.

Huang Mao opened his eyes and asked, "is it expensive?"

"It won't be too cheap. That's the expense." Yang Rui turned his mouth.

Huang Mao also instantly realized that the experiments conducted by Huarui laboratory in a cheaper way would cost 20 million yuan in five years. If foreign companies hire 10 pharmaceutical chemists and two or three biologists, they would have to pay millions of dollars a year, let alone other costs.

"It's just too long." If it is five years to earn back tens of millions of yuan, Huang Mao does not think there is much income. There are too many factories with annual profits of millions or tens of millions in China. Now the annual expenditure of Huarui laboratory is more than one million US dollars. Especially in the ongoing PCR lawsuit, the fees charged by American lawyers are soaring, and 20 million RMB is not enough to fill the hole.In this way, when it's time for lunch, Huang Mao sits beside Yang Rui, smiles at Grace, and says in Chinese, "Yang Rui, otherwise, don't spend all your time on desferridone."

"Why?" Yang Rui asked strangely.

"Five years!" Huang Mao sighed and said, "Yang Rui, don't blame me for what I said. You don't think that you will be like this in the future because of your high efficiency and achievements. It's impossible. You are 20 years old. It's the most successful age. Why do we have juvenile classes in our country? It's the hope that the scientific research life of scientific researchers will be longer, and they will start to do research at the age of 20. Like you, the high-yield period can last to 30, 35, or even 40. In these 20 years, it will take twice as long as the ordinary scientific researchers. "

After a moment's pause, Huang Mao said, "if you think about it, you'd better do scientific research for 20 years. Do you need five years to do desferridone? I'm not saying that it's not important to remove iron and ketone, but in the current animal experiment, I can do it, Lao Tu can do it, and Wang Xiaoyun can do it. Why do you waste your golden time on it? How many things can you do in five years? "

Yang Rui was stunned by Huang Mao.

In his drug group, there are only Wang Xiaoyun, Wei zhenxue and grace who volunteered. In fact, because the animal experiment is relatively simple, he is not willing to waste the time of the calves.

People like Huang Mao and Li Wenqiang are capable of publishing cell level articles in the future. Why use them in simple physical work.

However, Yang Rui has forgotten how much time he has to spend on it.

After careful calculation, the whole animal experiment was only carried out for two weeks, but for a researcher, two weeks is a lot of time.

"It's a vacation, a change of mind." Yang Rui smiles and explains to himself and Huang Mao at the same time.

Huang Mao is dumb.

Wei zhenxue, who is not far from the table, is listening with his ears erect. He is the only one who can do this kind of thing. At this time, he coughed and said, "people are different. Some people go out to play on vacation, some go home to sleep on vacation, and some pull the spine of mice on vacation..."

"I didn't move a mouse." Yang Rui explained again.

"I'm wrong. Some people like to watch people pull the spine of mice on vacation." Wei zhenxue laughs and says that he is perfect.

Yang Rui is speechless, suddenly also feel whether he has abnormal tendency. After a while, Yang Rui thought that it's no big deal not to be abnormal or biological.

"I'll take another week off, and if it doesn't work, I'll think about change." Yang Rui stood up and patted Wei zhenxue's neck twice, then put it down.

Wei zhenxue only felt that he had goose bumps all over his body, and the warm heart behind his neck was cool.

Yang Rui's thumb is on Wei zhenxue's neck bone, thinking about how to speed up the progress of animal experiments.

As a simple arrangement and combination elimination experiment, the progress of animal experiments can only be changed according to the amount of resources, and the space for technology to play is very small, because no matter how good the technology is, you can't see the change of a compound in human body or animal body.

If you don't try, who knows the effect of the compound, whether it will be metabolized or enriched, whether the metabolic pathway is as expected, and whether the metabolites are beyond imagination

Yang Rui knows.

……