Chapter 789

Fanlunding watched the rats being transported into Huarui laboratory. His face was uncertain.

Animal experiment is a great progress in the development of a new drug.

The vast majority of new drugs will fail in the synthesis stage after passing the target screening. For example, if coenzyme Q10 is not directly extracted from animal tissues, it will enter the market at the high price of health care products, and there is no possibility of commercialization.

This is also because coenzyme Q10 is not effective enough. If it can really treat heart disease, rather than a small auxiliary effect, pharmaceutical companies in various countries have already spent billions of dollars to try to synthesize it.

Although the synthesis of organic molecules is difficult, it is just a doctoral dissertation.

Of course, there are some doctors who can't finish their graduation thesis in any case, so that they can't graduate in five or six years.

In any case, entering the animal experiment means that a large number of chemical molecules have been synthesized. If they are sold now, they will be able to get a lot of profits.

Fan lunding was in a trance when he thought of the prize Yang Rui might have won or lost.

"This Chinese, does he know what he is doing?" Fanlunding thought that if he had the ability to synthesize more than 30 compounds a year, he would have made millions a year, and he would not want to live in a third world university.

It took Yang Rui less than two months to synthesize so many compounds, even if there was theoretical research - this is the place where van lundinic acid is more important. When did Yang Rui do the theoretical research? Fan lunding now knows that Yang Rui has successively completed the semi synthesis of coenzyme Q10, the research of potassium ion channel and the invention of PCR in more than a year, and then wrote a book on genomics

Valentine had no idea where Yang Rui's time for theoretical research came from.

Although many scholars have famous high birth period, such as the famous year of miracles, the Latin word is used to call Newton in 1666, when Newton left Cambridge to return to his hometown in order to avoid the plague. In this year, to be exact, from 1665 to 1667, Newton constructed calculus and established the law of gravity, The experiment of decomposing visible light into monochromatic light is equivalent to reshaping the three fields of mathematics, mechanics and optics.

The miracle year of English belongs to Einstein's 1905. In this year, Einstein founded the special theory of relativity and published two papers "on electrodynamics of moving body" and "is the inertia of an object related to the mass it contains?" in the same year, another three heavyweight papers brought Brownian motion and quantum theory to a new level, any of them, They're all Nobel class.

Compared with Newton's miracle year and Einstein's miracle year, Yang Rui's 1983, or 1983-1984, is not enough to be praised. Although PCR is strong, it is not as strong as calculus or quantum theory. Gravity and special relativity are immortal works, surpassing PCR by more than one order of magnitude.

However, for Valentine, these things are more than one order of magnitude.

Standing with Valentine, watching the rat cars coming in and out were Frankie and Arnold.

When they heard fan lunding's words, they looked at each other with a smile, thinking that Yang Rui certainly knew what he was doing.

Frankie's butt has been crooked for a long time, and he is too lazy to talk about it. Arnold thinks that Valentine still has the use value, and comforts him: "no matter what Yang Rui thinks, we can achieve our goal."

Fan lunding wry smile: "I thought that making 20 kinds of active substances, we can bring down Huarui experiment..."

If a small biological company can produce 20 kinds of backup targeted active substances in three years, it will be lucky.

Time, for a biological company, is also a huge cost, which also implies the problem of success rate. In short, the cost of achievements made in three years is more than three times that of achievements made in one year.

If Yang Rui takes three years to make 20 kinds of active substances, the materials and manpower consumed during this period will naturally be what he needs to do experiments every day for three years.

However, it took him two months to make 20 kinds of active substances, which can't be regarded as achieving the goal.

Arnold had hoped that Yang Rui would sell the catalyst formula of coenzyme Q10 because of the increasing scientific research budget. On the contrary, Yang Rui could completely reduce the scientific research budget, making his plan almost bankrupt.

Arnold wiped his face and said, "they are going to do animal experiments on more than 30 compounds at the same time, which will also increase the immediate cost. You should stare at them first, see the results, and then decide how to do it. Don't lose heart."

"Grace joined Huarui laboratory, they do animal experiments, the probability of success is very high." Valentine played the retreat."You should continue to play your role and strengthen guidance, for example, try to improve their standards. Animal experiments are also expensive, and the results will only be known sooner." Arnold kept cheering Valentine up.

"Yang Rui is a young man in the pharmaceutical field, but he doesn't just listen to what you say. Don't raise the standard too far, otherwise he will take you back," Frankie said

Fan lunding nodded silently and said, "there's no need to improve. I'll translate FDA's requirements directly to him. Such a team can't pass the test in any case."

FDA In the industry, it has been evaluated by too strict standards. The same drugs can be listed in Europe, but not in the United States.

In the 21st century, this polarization has become so serious that there are more than 200 kinds of new drugs in Europe than in the United States. It has become a business to bring European good drugs back to the United States.

If anyone can buy the US management right of a European drug and pass it through the FDA's animal experiments and phase III clinical trials, it often means hundreds of millions of dollars in revenue.

Therefore, it is a very high requirement to follow the requirements of FDA in the development stage.

Half of the drugs will be disqualified - Europeans don't want the failed products under the FDA standards, they want the successful products that can pass their own standards.

Fanlunding get Arnold's clear instructions, also don't see the mouse into the cage, immediately returned to copy the rules.

On the other hand, a large number of mice and rats were put into the compound not far away.

Yang Rui's Huarui laboratory has a large number of vacant land. In order to avoid being taken back by the government, it has built yards one after another.

The yard for holding mice and rats has been designed for a long time. For biological laboratories, laboratory animals are also indispensable.

Yang Rui even designed the location of the gorilla in advance.

Now, however, mice and rats are needed.

The mouse is more lovely. It is bred from Mus musculus. As one of the smallest mammals, the mouse has been studied most thoroughly and is the most convenient for primary experiments.

Rat is rat, it has many varieties, including Chinese brown rat, that is, ordinary house rat, relatively speaking, it is not so cute.

But whether cute or not, these mice and rats have to contribute to the development of human medicine and biology.

Carefully speaking, this is a very cruel act, but the reality is so cruel.

Animal experiments for cosmetics are most vulnerable to attacks by society, especially animal organizations, so that many people initiate activities that do not use cosmetics or "be free from cruelty". However, even girls who are fond of beauty can refuse to make nail polish with beautiful rabbits. You can refuse sunscreen Concealer isolation, moisturizing, body butter, baby oil, day cream, night cream, facial mask, hair spray, hair spray, cancer, AIDS, diabetes and Parkinson burn patients, but they can not refuse to save their own medicines.

The only thing we can do is to ensure the necessity of using experimental animals and the living environment of experimental animals.

Grace carefully checked each cage, labeled each cage, and carefully fed a small amount of water to the mice and rats, and asked about the indicators in simple English.

Wei zhenxue graduated from the Department of chemistry. He had never done animal experiments before and was a little afraid of mice. He looked at him from a distance and said, "if my wife is so kind to me, I'd like to be a mouse."

"Write down these words, and we'll see them in a few days." Wang Xiaoyun laughs twice and goes forward to help.

Wei zhenxue looked at the working state of the two ladies, and rarely said a good word: "Lao Tu is lucky. If you want to marry a wife, you have to marry a good wife and a good mother."

Tu Xian twitched his mouth twice, shrunk his neck, patted Wei zhenxue on the shoulder with deep feeling, and said: "if the woman in biology department is good to you, you have to think about her deep purpose."

……