Chapter 784

In Huarui laboratory, van Lundin was very silent. Apart from talking about some things in the development of new drugs, he seldom talked or even talked. Sometimes, he even looked at Yang Rui making one deferrone derivative after another with a resentful look.

Yes, one after another of the deferonone derivatives.

Yang Rui completely listened to van lunding's opinions and decided to make more derivatives of deferrone for backup.

The development of new drugs is a test of human character, because the extraordinary high requirements of the public for pharmaceutical enterprises increase the risk of clinical trials infinitely. Drugs with the same chemical structure that can pass in Europe may not pass in the United States, and those that pass this year may not pass next year.

Even Pfizer can't guarantee that a certain chemical structure of its drug will pass the FDA's review. Different chemical structures will have different side effects, and everyone's reaction to the drug is different. No one can guess whether you will encounter a patient's stress reaction in your next clinical trial.

Modern clinical trials can not cover the whole population, and are not developed enough to screen clinical trials through genes. Therefore, unless it is an important drug expected by the company, a clinical accident will be enough to ruin the future of a good drug.

But the solution, can only be like buying lottery tickets, as much as possible to buy some, try to cover some comprehensive.

Of course, under such policy restrictions, public access to drugs is not necessarily the one with the least side effects and the best efficacy, but the one with the best luck.

In other words, Yang Rui is not sure that the chemical structure of deferrone used by the former Indian company must be the one with the best curative effect and the least side effect.

Similarly, Yang Rui is not sure that the most fortunate chemical structure will still stand out in another clinical trial.

Therefore, after being reminded by van lunding, Yang Rui can only make as many active substances as possible.

And his method of making new active substances is also very simple, just copy the original generic drugs.

Different generic drugs have different chemical structures. As generic drug companies, if they want to imitate some original drug, they often make preparations three or four years or even six or seven years in advance. In such a long time, weak generic drug companies can always imitate several similar chemical structures, Then enter the clinical trial stage - the audit system of generic drugs is much more relaxed than that of original drugs. However, there are not many generic drugs that can pass the supervision.

But for Yang Rui, who has scanned Pharmacopoeia and other books, if one or two generic drugs appear in one country, there will be too many generic drugs in the world. Especially for the drugs around the 1990s, the structure patents of generic drugs are invalid, and the generic drugs of all kinds of generic drugs are even more different, some of which are quite creative.

Yang Rui doesn't have to think too much at all, just follow the established steps to make drugs with different chemical structures in order.

In fact, this kind of feeling is a bit like the work of graduate school, which is just to achieve the set goal.

Although boring, in fact, there is a slight sense of achievement.

After all, the average day to make a new compound, this kind of thing, or it is easy to let people's career burst.

Think of the ordinary people with a metal hoop, a trash can are happy like doing a big thing, synthesis of a new compound - well, ordinary people do not care about this kind of thing.

Even Wei zhenxue turned a blind eye to Yang Rui's behavior.

Although he graduated from chemistry and has worked in the Institute of coal science for many years, China's chemical industry has always been committed to absorbing the nutrition of western countries. It is better to do a new chemical compound one day than anything else. Sometimes it can be used as propaganda.

However, van Lundin did not work in the Institute for many years.

He has been studying and working in Cambridge for many years, and he has never seen such a fast way to make new compounds.

Valentine even couldn't help calling his former tutor. At the end of the call, both sides listened to each other's breath for a minute, even if the conversation ended.

Since that day, Valentine has been more silent.

Wei zhenxue asked fan lunding a lot of questions for the reason of giving Yang Rui a hand. He didn't get a warm and detailed explanation. He was very upset. When doing the experiment, he said to Yang Rui, "this foreigner has a dark personality. You see, he keeps his head down all day. It seems that others owe him hundreds of thousands of dollars. He suffers too much."

"People don't like to talk." Next to him is Wang Lei, a scientific researcher with tiger head and tiger brain. He is currently a professional scientific researcher and has been working with Yang Rui for a long time.

Wei zhenxue shook his head: "you didn't see how much he said when he just arrived at the laboratory. I think he didn't want to talk because he saw that we had made achievements, or he was just jealous.""No, they graduated from Cambridge. They are jealous of us." "I heard that the monthly salary of foreigners is tens of thousands of yuan. Don't Cambridge graduates want more?" Wang said

"Those who graduated from Cambridge are not from Cambridge, but from their family. As far as we do desferridone, they don't have it." Wei zhenxue also shook his head, and said: "tens of thousands of yuan a month is nonsense, we have not seen foreigners, thousands of yuan a month is not young and old, to fall to me, I will save money, spend 50 yuan a month, save money, save enough 200000, I quit my job to go home, eat bank interest every day, no longer need to nest in the laboratory every day?"

Huang Mao, who was doing polymerase experiment nearby, heard this and said, "Lao Wei, we work in the laboratory not for money, but for common ideals and pursuit."

"And then?"

"So, you're not in the lab because you don't have 200000. You're in the lab for our ideals and pursuits."

Wei zhenxue stared at Huang Mao for a long time, sighed and said, "you are wrong. You are in the laboratory every day, so there are no hundreds of thousands."

Huang Mao is dumb.

Wang Lei "Chi" smile, and quickly shut up, said: "I mean, researcher Wei actually likes to nest in the laboratory, otherwise, why not go back after work."

Wei zhenxue snorted, looked around and said, "what do I do when I go home? There's Wang Xiaoyun in the lab, and I only have Huang Lianpo when I go home. "

Wang Xiaoyun, who was called by her name, looked up in surprise. Not far away from her, comrade Tu Xian, Wang Xiaoyun's husband, gently sniffed a can of liquid to hand.

When Wei zhenxue saw it, he laughed and said, "Lao Tu, you have no sense of humor."

But Huang Mao laughed and said, "I think it's very humorous."

Yang Rui and others also laughed. Liquid smell is a very terrible poison, its wound is yellow, will not scar, will not purulent, so rotten, splashed on the face than sulfuric acid, a bit in line with the definition of yellow face... This is the reason why several people laugh, only belongs to the laboratory joke.

Fanlunding listened to their laughter. He felt uneasy. When he went back in the evening, he couldn't help calling his tutor.

"How many active substances do they make now?" The tutor asked Valentine.

"Twenty one." Valentine's bitterness can be heard through the overseas telephone.

"Two weeks, from 12 to 21?"

"To be specific, it's 11 days, nine more," Van Lundin said

"Unlikely..."

"That's what I want to say... Is it possible that he did a lot of theoretical research in advance... And then, now, through experiments to verify it."

"That's too fast. But... "

"But what?"

The tutor at the other end of the phone took a breath and said, "if it's Yang Rui, it's not impossible."

"Why“ Valentine was surprised. He never thought that his proud teacher would say that.

"You probably haven't known the academic circles for a long time. Do you know how people evaluate Yang Rui now?"

"I know that his recent studies are very famous, and his articles have been published in cell and nature, but I don't know the academic evaluation." Where can Valentine know the academic evaluation of a scholar? He has been away from the academic circle for too long.

My tutor in Cambridge said solemnly, "there are many comments, some of which I didn't believe before."

"Yes? What are you talking about Valentine had the feeling of watching horror movies, and his goose bumps stood up.

His tutor's voice was more slow and heavy: "some people say that Yang Rui will win the Nobel Prize sooner or later, and maybe he will win the Nobel prize so early that he will break the record of the Nobel Prize in physiology and medicine. Originally, I didn't believe it, but now it seems that it is really possible."

Valentine's body shuddered.

The word "Nobel Prize" is more exciting than gold in a room for scholars and researchers in industry.

People with Nobel prizes may be able to mobilize more resources than people with a room full of gold.

And that sense of honor is nothing to add.

"I can help you to ask a few people to see if there are any scholars who know about ferroketone. You can follow Yang Rui to learn more. This is a rare opportunity." The tutor stopped for a moment and said, "last month, we began to use PCR instrument in our laboratory. It's a very simple but easy-to-use instrument, a cross era invention."……