Chapter 591

"This is the first priority project, and it's the most important project in the years since my lab was established." Yang Rui convinced all the people in the laboratory, but also the lawyers who came from Hong Kong.

Of course, a lawyer is paid and has to work anyway, but whether he understands the importance of the project also determines his way of working.

Big name lawyers can make money everywhere, and they will do the same job as taxi drivers in rainy days. Simple patents have no interest, so they can do it more easily. This kind of patent may expire without a lawsuit challenge in their lifetime. However, Yang Rui's expectation that the patent is time-consuming and laborious. He wants others to do it for you, You have to prove that your patents are worth doing.

Lawyer Yue Ting is very professional with two assistants, listening carefully. He has worked as a patent lawyer for more than 30 years, and I graduated from the Department of physics of the University of Hong Kong. His science background has led him to the road he is today. Yang Rui deliberately said that it is simple, so he can understand most of the contents.

That is about half an hour, Yue Ting proposed to see the X-ray.

DNA You can't see it with naked eyes, nor can you see it with ordinary microscope. In fact, it's idle to see it, and you don't know it.

28 DNA with a base pair can't get an answer even if you ask it "who are you?".

To prove the success of PCR, we need to use the hybridization signal on the X-ray.

Yang Rui is looking at another company lawyer next to him first.

The company lawyer also came from Hong Kong, but he belongs to the company lawyer who has signed a long-term contract with Huarui company and belongs to Yang Rui's own people. After the latter nodded, Yang ruicai went to get the X-ray.

In fact, there is nothing to hide, this belongs to the professional category of things, copy all can't go.

The reason why Yang Rui did the experiment again was to have these seemingly useless proofs.

Otherwise, he would just copy the paper directly.

However, if you just copy a paper, you can't pass the academic review one after another.

Many papers that have changed the world are very short -- Tu youyou's Nobel Prize winning paper is titled "a new sesquiterpene lactone artemisinin", signed by the artemisinin structure research collaboration group, and the full text is only one page. The DNA double helix written in each student's textbook also won the Nobel Prize for Watson and Crick. The full text is only half a page.

It's hard to get a long paper, and it's hard to get such a short one.

At least, it's very difficult to copy, and patent application can't be like a paper.

Patent application is a nagging process. It's about how many patents come from.

Some large companies, in order to apply for a patent, will list hundreds of parallel patents, all in order to protect the intermediate core patents.

Therefore, many large companies have tens of thousands of patents a year. It's not that they really have tens of thousands of patents. It's good to have thousands of patents. The rest are all the most exciting patents.

However, the patents should be carefully written, which will cost the time of lawyers and the time of the patent office. In the final analysis, it will cost money.

And it's very expensive.

This is especially true for mainlanders in '84.

Yue Ting calculated a number in his mind and shook his head in his heart.

Of course, he won't say to Yang Rui, "you don't need to patent this research in this way." if he is a white man, he will make money first without saying a word.

Facing Yang Rui who is in the mainland, Yue Ting wants to save some money for him. He also thinks it's too troublesome. He thinks, "I understand what you just said, but I think it's a bit expensive, especially when you ask for applying for multiple patents at one time and applying for patent protection, which costs at least a million dollars, Because there are other lawyers' salaries, the amount of this part can not be determined, only a lot more. "

On the one hand, he was bluffing Yang Rui, on the other hand, he was telling the truth. If he followed Yang Rui's request, he would have to spend millions of dollars, which was not much less.

If you encounter a patented submarine, you have to fight a lawsuit.

If you want to make your own patent submarine, you have to pay a lot of money.

Patent barriers have always been something that big companies like. When small companies do this, they can only do it steadily, which belongs to self-defense.

Yang Rui had a series of patent applications for coenzyme Q10, but the requirements at that time were more than one order of magnitude lower than those at present. So is the strength and price of the lawyers.

However, coenzyme Q10 is only one billion US dollars in the market. The profits allocated to jericham are one billion US dollars, and the profits allocated to patent owners are one million US dollars.PCR is a terrible monster. It may be the first blockbuster in the field of biotechnology, eventually creating a market of 100 billion US dollars. Historically, PCR represents a technology patent worth 3 billion US dollars.

It doesn't include the controversial high temperature resistant polymerase.

Now, Yang Rui has made up for the short board of high temperature resistance, and the profit may rise sharply.

From the heart, Yang Rui has to apply for the patent at all costs.

However, whatever the cost is always a false proposition, money is the last word, and capital is always the bottleneck.

Yang Rui doesn't have a million dollars.

Recently, Huarui laboratory has been spending money like water, and he is still afraid to cut it off... Although the PCR experiment can be patented, it is still a long way from the complete completion of the academic research, and it still needs to continue to invest, and there is no return in the short term. He will apply for more patents in the future, including PCR patents, and maybe Huang Mao and others have made achievements, Money is everywhere.

The enterprise will have the problem of capital chain, and so will the laboratory.

Yang Rui's income is only the dividend of Jericho.

Once every three months, we can get a million dollars more now and only 700000 dollars less now.

If the money is used for personal life, the rich and powerful don't know how to spend it, and they can buy a Ferrari in a few days.

However, I don't know how much is more expensive than Ferrari in the laboratory

Yang Rui did not speak at all.

"Mr. Yang Rui, you should also pay attention to the issue of patent disclosure. Only a few of the major patent countries in the world, such as the United States, have no patent disclosure system. But if you want to apply for a patent in multiple countries, you need to disclose the patent content. Anyone can search for it. Once it is found, your technology may face competition. " Yue Ting knew that Yang Rui's research had not been completely completed, so he wanted to persuade Yang Rui from this angle.

But Yang Rui didn't even think about it and said, "other people can't do it faster than me. Even if they make it public, they won't have time."

"But disputes can increase costs."

"There's no way. You can't just stop applying for a patent. Mr. Yue, for PCR project, I'd rather spend all my money to do it. Please take more trouble... "

Yang Rui said so. As a lawyer, Yue Ting nodded and said, "OK, I'll finish the preparation and application as soon as possible. One month at most, you can find the public records. "

"That is to say, I have a month to go before I can publish the patent?"

"Maybe only 20 days, if our application goes well. We are professional patent lawyers, much faster than ordinary patent firms. " Yue Ting is quite proud of this.

Yang Rui nodded slightly and said: "up to now, I have carried out this project independently. Now the original stage is over, and the next step is to enter the verification and improvement stage. I'm going to let the laboratory staff intervene. Is this appropriate? It won't affect the patent application

"Of course not." Yue Ting laughed.

Hua Rui's company lawyer also explained: "the employees have signed strict confidentiality agreements, but also give up the relevant demands, you can rest assured."

"I hope both of you will check again independently."

The lawyer of the company was a little unhappy, but he could only say, "I'll give a copy to Mr. Yue."

"Independent audit. If you have any problems, please report to me separately. It doesn't matter if there are loopholes in the previous contract. We can sign a new one now. I don't want to see another loophole after other people get involved. "

"You really should be a lawyer." Yue Ting didn't think much of Yang Rui's caution, but he understood Yang Rui's attention to this matter and corrected his attitude.

For patent lawyers, they don't need to judge the value of the patent. The attitude of the employer decides everything. If an employer feels that he has invented the fragrance law, what a patent lawyer should do is to protect the fragrance law without scoring the fragrance degree of the law.

"Don't be afraid to waste paper. Contracts must be tight." Yang Rui warned again.

This is a Nobel Prize achievement, and I don't know how many lab colleagues are suing for it. When Waxman discovered streptomycin at that time, he was sued by his doctoral student, SAZ, who was the direct discoverer of streptomycin strain. Finally, the two settled out of court. Rutgers University issued a statement, admitting that SAZ was the co discoverer of streptomycin in the legal and scientific sense, And give sarz 120000 US dollars of foreign patent income and 3% of patent income

Naturally, the academic community doesn't agree with this. SAZ is no more than a dog under Waxman. Waxman's laboratory has 50 research dogs. After Waxman has taken the correct screening, streptomycin can be found in any of the 50 research dogs, It's just a matter of time.There was nothing wrong with sarz in the subsequent Nobel Prize. As a so-called co discoverer in the sense of science, no scholar agreed with him at all.

In the end, sarz has no place in academia, but he actually takes away the patent share.

Yang Rui doesn't want this to happen to him.

When he was in graduate school, there were many postgraduates and doctoral students like sarz around him. When everyone is drunk, they will say: "I do all the work, but the result is the boss's, the first author is the boss's... Unfair!"

Yang Rui is a supporter of this injustice. Workers are worthy of respect, but they are not competitive and have no right to be praised for their intellectual achievements.

The physical labor dog in the scientific research world, even people are not qualified to win prizes and get money!

Since sarz and Waxman, laboratories all over the world have also updated their laboratory codes and contracts. There are countless models. Yueting and the company's lawyers understand Yang Rui's psychology, and then they are busy.

That night, Yueting and the company's lawyer met with Yang Rui respectively to revise the contract.

The next morning, Huang Mao and others re signed the contract and began to participate in the PCR project.

Indeed, they have not participated in the discovery of PCR, and it is natural for them to give up the relevant rights. In addition, they will not be aware of the great potential of PCR like Yang Rui.

At the request of Yang Rui, in addition to Huang Mao and Tu Xian continuing their original project, Wang Xiaoyun, Wei zhenxue, Li Wenqiang, Duan Bo and Zhang Xuetong all joined the PCR project team one after another.

Their job is to complete a PCR experiment with the highest "golden rule".

The golden rule requires amplification of a single copy gene from a microgram of human DNA.

This will be a long and arduous process, especially for the first generation PCR technology, Li Wenqiang and others who have just come into contact with PCR, and Zhang Xuetong, who is responsible for the production of oligonucleotides and other raw materials.

Yang Rui began to write papers independently.

Unlike the potassium channel project, PCR technology is very simple, simple and perfect, with a long history.

……