Chapter 145

After Yao Yue started to work, she was still a little nervous.

But soon, she found that she didn't need to worry.

Because Yang Rui works so seriously that she has no time to care whether her dress and white coat are really together.

It's too much work to produce coenzyme Q10 by plant extraction.

In particular, Yang Rui is ambitious. If he wants to establish a research and development chain, this task is even more important.

In order to produce cheaper coenzyme Q10, the most important step is to extract solanesol from tobacco leaves, and then use solanesol as the intermediate to synthesize coenzyme Q10 by chemical method.

The extraction of Solanesol from tobacco leaves has already been studied.

Even using solanesol as raw material to synthesize coenzyme Q10, there were related papers and laboratory achievements in 59 years.

However, the paper is the paper after all, and the research is the research after all. Just like the pure chemical synthesis of coenzyme Q10, since the 1960s, there have been many related papers and researches, and more than one team of people have obtained coenzyme Q10 through chemical synthesis. However, until half a century later, chemical synthesis of coenzyme Q10 still can not be industrialized.

It took about 30 years for semi plant extraction and semi chemical synthesis to mature. The key factor is to use 90% purity solanesol as raw material.

Yang Rui may be the only one in the world who is aware of this point now.

It can be said that in such a word, it can be exchanged for an industry worth billions of dollars in the future.

Unfortunately, Yang Rui can't just say that.

If he uses an experiment or a paper to talk about it, he may be highly praised and affirmed by the biological community, but money is not necessary.

There are too many super pharmaceutical companies in Japan, West Germany, the United States, France and the United Kingdom, which can use strong research teams and pure gold lawyers to leave Yang Rui out of the revenue area.

It's a bit arbitrary to say that large pharmaceutical companies are the most despicable companies in the world, but who wants to say that they are not despicable must get the lottery.

Even the employees of pharmaceutical companies dare to say that our company is charitable at most, but they dare not say that their company is charitable.

Therefore, Yang Rui must build a series of key technologies around the core technology, and then use a series of technologies around a series of key technologies.

For example, the synthesis of 90% purity solanesol requires a series of key technical support.

The advantage of this barrier is that Yang Rui does not need to apply for a patent for the core technology, or simply make a patented submarine, and only produces finished products for sale in a strictly confidential way.

This is also the magic weapon for small and medium-sized biotechnology companies to survive.

80 In the early s, many biotech companies didn't understand this, thinking that patents could protect themselves. As a result, one by one, they were killed by large pharmaceutical companies.

In recent years, the average life span of biotechnology companies in the United States is only 36 months. If we add a sum of legal fees, most of the medium-sized biotechnology companies with a capital of less than 50 million US dollars will not survive for 18 months.

At the level of large pharmaceutical companies, let alone delaying for 18 months, lawsuits that they have delayed for more than eight years are everywhere.

This is one of the reasons why Yang Rui does not dare to make medicine for the time being.

Western medicine has a fixed name, usually a compound. Moreover, most of them are derivatives of known compounds in the pharmaceutical field, except for different side chains, which is not surprising.

For example, it's very easy to imitate this kind of medicine. If you make money, it's almost natural to be imitated.

The production technology is quite different. As long as we do a good job in confidentiality and upgrade our technology, we can maintain our monopoly interests for several years.

Biotech companies make a few years of Monopoly money, no matter how small the field, it means a lot of money.

Japan's pharmaceutical companies have used semi plant and semi chemical synthesis, that is, five or six years, and accumulated enough funds to complete the research and development of microbial fermentation method. At the same time, the dividends are distributed to the weak.

Now Yang Rui has developed the technology of plant extraction and semi chemical synthesis, and he can earn more money for several years.

Thinking of this, Yang Rui is also full of energy.

In a short weekend, several verification experiments were completed.

At the same time, Yang Rui also began to write a review article, such as the research status of solanesol.

However, it is difficult to publish such articles, especially in better journals.In Europe and the United States, especially in the United States and the United Kingdom, reviews are often written by experts in the field.

Of course, their motivation for writing reviews is usually not so pure. Most of the time, Daniel wrote a review, also to mix a paper index. Because many foreign schools also have the hard requirement of how many papers to write every year or every few years, some big cattle either out of laziness, or out of excellence, unable to complete the required number, write a review to muddle through.

Because it's advanced science popularization, we don't need to do in-depth research. After looking up some information, we can usually write a summary in a few days.

Domestic reviews are often written by gentlemen who are far away from Daniel. Some graduate students who can't write a thesis or want to write a SCI, some young lecturers who can't finish the task, or busy associate professors are all big writers of reviews, and their level is naturally uneven, so that some colleges and departments simply list the reviews separately.

However, in the 1980s, the Chinese academic circles were not so particular about it. Limited by the level, the summary is still a very popular category, and people who rely on it to mix titles are like crucian carp across the river.

Yang Rui doesn't want to waste so much information, plus the technical barriers of the paper is the more the better, he is not polite to start writing.

Lu Zhi, who helped in the laboratory, saw that his writing was easy. In one afternoon, he wrote a large page of paper. He couldn't help asking, "is that how you write a paper?"

"This is Yang Rui's smile:" I'm different from them. "

Now, even Yao Yue asked, "what's different?"

"Talent." Yang Rui pointed to his head and said, "I have a lot of things in my head."

"You mean my head is empty." Lu Zhi is not proficient in doing experiments, so she has few chances to contact the instruments. What's more, Yang Rui is unfamiliar with the instruments here. In the past two days, her performance is not as good as he Cheng, a middle school student. She has some emotional accumulation.

A silly girl like Luzhi, who had an idea, immediately poured it out and couldn't save it.

Yang Rui chuckled twice, silent acquiescence.

Lu Zhi was so angry that he grabbed Yao Yue and said, "let's go. If we don't work for him, we will not only be tired, but also be scolded. We are capitalists. Who does it for you, who is the dog. "

Yao Yue is in a dilemma. Yang Rui said: "thank you for making braised pork in brown sauce in the canteen at noon."

Luzhi stopped unconsciously. For a moment, she called softly: "Wang!"

Yao Yue couldn't laugh or cry, so she was ashamed to say: "Luzhi, you can't just..."

"Just what?"

"Just call..." Yao Yue stamped her foot, and then said everything.

Lu Zhi said: "what is this? When the educated youth order, if the kitchen makes a pot of braised meat, everyone can queue up for a day. If it's over and there's no braised meat in the end, everyone can rush up and kill the team leader in the kitchen. "

The last sentence is obviously threatening Yang Rui.

"Have you ever been an educated youth?" Yang Rui quickly digs off the topic.

"There are many educated youth in the school. I went back home to study for a year before I was admitted. Fortunately, I was admitted, otherwise I would have to go to the coal mine. One of my former classmates, who went down to the coal mine to do mineral processing for two years, couldn't sleep at night with tinnitus. He said it was full of machine sounds. " Luzhi complains and congratulates.

He Cheng, who has been doing the experiment all the time, heard this and suddenly said: "my second cousin sold the pigs at home last year in order to get into the coal mine, bought cigarettes and wine as gifts, and then arranged temporary work for him. He didn't become a regular until two years later. They all eat vegetarian dumplings during the Spring Festival. "

It's better to go to the coal mine than to study in the coal mine. The answer immediately silenced two college girls.

Yang Rui didn't like the atmosphere. He coughed and said, "Yao Yue, you can also write an overview and show it to me next week."

"Me? I still can't understand some words... "Yao Yue was a little nervous. Now there is no search engine can help translate English, do not know the words have to find out one by one, rare professional English only professional dictionary can find out, the workload is huge.

Yang Rui shook his head: "I don't want you to write in English. First, I'll write an article in Chinese. Anyway, it's not a waste of experience. I'll fix the paper for you, and then I'll teach you to write a letter of contribution. Your signature is your own. "

Just like the great bull of later generations, Yang Rui disdains to keep his name in the domestic journals, not to mention this kind of practical review articles.

Yao Yue relaxed for a while, nervous again, whispered: "can I write it out?"

"How do you know if you don't try. All right, you can go pack up and go back after lunch. Yao Yue, if you have any questions, please send them to me and write to me. Well, I have an experiment for you, and I will also write to you to explain the requirements and steps of the experiment. When you have the results, please send back the details. Remember to memorize English words and start reading English literature next month. " In addition to the fact that email has become a mail, Yang Rui's requirements are similar to those of his tutor when he was a sophomore.Nowadays, there are few graduate students. Excellent undergraduates are supposed to undertake the task of assisting experiments. Now Yang Rui has an understanding of Yao Yue's experimental ability. As long as she doesn't assign tasks beyond her ability, there won't be too many mistakes.

Lu Zhi meditates on the braised pork and goes to the dressing room lightly. Yao Yue leaves a little hesitant, not only yearning for the laboratory and people, but also looking forward to writing her own paper.

"If the students in the class knew that I had the opportunity to write and publish papers independently, they would be envious." Yao Yue's vanity is also small fermentation. She is only a sophomore this year. If she has the chance to publish a paper, she will be the man of the year in Hedong University.

……