Chapter 740

At 12:15 in the middle of the night,

an hour before taking off, Xu mang sat in the VIP waiting hall with a trace of anxiety between his brows. He received a call from academician Zhong and was told that his AI program had made a very serious error. There were several differences between the experimental data and the AI data.

"No..."

"why?" Xu mang looked at the contents of the notebook screen, his expression was very confused, and the data on both sides could not match. This is very strange. Generally speaking, it is impossible to do this. He has never encountered it.

Is it...

man, are you going to capsize in the gutter?

Facing this kind of thing that may happen, Xu Mang's self-esteem is unacceptable, has been used to success, but suddenly face failure, don't say... Don't know how to deal with, fear? at a loss? Confused?

In short... At this moment of Xu Mang, heart mixed Chen, unspeakable a kind of pain.

If there is a problem with one of the experimental data, even if there is a problem with all seven data, it is very clear that the problem must be his own mistake. It seems that Xu man-2 artificial intelligence system is going to be a tragedy. It is either to push it down and start again, or to develop No.3.

"Professor Xu?"

"Your coffee... Keep your mouth hot." A beautiful and generous stewardess brought a cup of coffee for Xu mang. In fact, this stewardess should not have served Xu mang. However, the boss of magic capital personally called the chairman of Mordo International Airport to take good care of Xu mang. Only then did a stewardess serve Xu mang alone.

"Thank you."

Xu mang replied absentmindedly. He looked at the data on the screen and turned a blind eye to the stewardess beside him. At this time, the mobile phone on the side rang and the caller was Yang Xiaoman.

"Hello?"

"So late at night?" Xu mang answered the phone and asked curiously, "if you go to bed too late, you will easily get wrinkles. You are still a beautiful girl. After a few days, you will become a yellow faced woman. Although I pursue spiritual beauty, the premise is that the other party's appearance should meet the standard."

"..."

"idiot... I'm worried about you, I can't sleep." Yang Xiaoman said: "what's the trouble? It's going to be the new year's day soon, and I'll let you go to the capital... I don't know how to be considerate at all. I used to have a happy New Year's day, but now I've added a lot of obstacles. "

In the face of Xiaoman's endless complaints, Xu mang just laughed and said calmly: "this is normal... In fact, I am very free. Many scientific research workers you don't know and don't know, they work harder than me... They are willing to bury famous people under the anonymity and achieve earth shaking things."

"Xiaoman..."

"I may not be able to come back this year. Don't forget to come to my home on New Year's Eve. My parents miss you very much." Xu mang helplessly said: "I have encountered a problem that can not be solved temporarily."

Yang Xiaoman was silent for a long time, and said in question, "I know... You can rest assured about the family affairs. I will take care of them all."

After that,

they whispered and hung up 15 minutes before takeoff.

...

after getting off the plane,

Xu mang saw the staff waiting for a long time.

"Hard work."

"Wait for me in the cold." Xu mang said with a wry smile, "is there anyone else in the Institute now? There should be no one at four in the morning? "

"Well!"

"Professor Xu, may I take you to the guest house first?" Asked the staff member.

Xu mang thought for a while and said seriously, "you send me to the research institute first. I can't sleep for the moment. By the way, the gatekeeper should have the key to the laboratory?"

"..."

"Professor Xu, why don't you go back to the guest house first? Academician Zhong asked me to take you to the guest house." "You just got off the plane, so you'd better have a rest. Tomorrow... You may be a little busy tomorrow."

"Oh..."

soon,

soon, Xu mang went to the so-called guest house, which was actually the place where he had been last time, which may be the reason for the coming Chinese New Year. Xu mang quickly moved in and came to his room, completely sleepless. He took out his notebook from his handbag and continued to look at the data.

According to the principle,

even if it is not the upgraded crispr-cas9 system, it should also have high target accuracy. But why is the error rate of the upgraded crispr-cas9 system 100%?

"Alas..."

"I'm going to die!" Xu mang lies on the bed and looks at the ceiling above his head. For a while, his emotion that he can't get rid of gradually comes to his mind. He really has no clue. He thought he had won, but he never thought that it was just opening Pandora.

Unconsciously,

Xu mang entered his sleep until he was woken up by the phone four hours later.

"Hello?""Well, I'll be right here." Xu mang made a haqie, and then went to the Institute of Biochemistry and cell biology of the Academy of Sciences.

Soon,

Xu mang met with academician Zhong, who is in charge of the Institute of Biochemistry and cell biology, Chinese Academy of Sciences. However, he is in a poor state with light bloodstains in his eyes. It seems that he didn't sleep well yesterday. Thinking about this, how could he sleep well.

"Professor Xu mang."

"I'm waiting for you at last." Academician Zhong said with a wry smile: "this gap is too big. Almost all your AI calculation results are wrong, and it is a very serious Miss target error. Professor Xu mang... What is the situation?"

Xu mang shook his head and said helplessly on his face: "I don't know, so I came to understand the situation in a hurry."

At this time,

academician Chu came in and was stunned when he saw Xu mang. He quickly asked, "Professor Xu mang?"

"This is Lao Chu, academician of Chu." Academician Zhong said.

"Hello, academician Chu."

After a simple exchange of greetings, the three began to talk about the root cause of the problem, but after ten minutes, there was still no clue. But the most embarrassing one was Xu mang. After all, all the problems were in his body.

Then Xu mang came to the laboratory and got more detailed information report. Then he applied to academician Zhong for a temporary office.

"Professor Xu mang?"

"Did you find anything wrong?" Academician Zhong asked.

"Not yet." Xu mang still shook his head and said helplessly: "but academician Zhong, don't worry... Since I promise to help you upgrade crispr-cas9 system, I will do it. By the way, can you give me a key to this office?"

"Eh?"

"Professor Xu mang?"

"Don't you go back?" Academician Zhong asked.

"Well!"

"Pride won't let me go back." Xu mang seriously said: "this matter can't be done, I feel very uncomfortable all over."

For a while, academician Zhong didn't know what to say. He had heard from his old friend, Xu Mang's second grandfather, that this guy's head was not ordinary iron, his temper was stubborn, and ten cattle could not be pulled back. Originally, he thought that there might be some water in it. Who ever thought that... Was true.

"Professor Xu mang."

"The Spring Festival is just around the corner, or we can do it later." Said academician Zhong.

"Forget it..."

"it's better to be here than to go back with worries." Xu mang said with a wry smile: "the only music is not as good as the public music, but the public melancholy is not as good as the only melancholy. Academician Zhong... You and the researchers in the Institute say, come back in the new year... I'll give them a satisfactory reply, let them relax."

After hearing Xu Mang's words,

academician Zhong knew that he was going to fight all the responsibility alone.

...

there are still three days to go before the Chinese new year,

the Institute of Biochemistry and cell biology of CAS is empty, and almost all of them go home except those who have been arranged for duty.

In the past few days,

Xu has not been idle. He has found the problem. In the upgraded CRISPR system, it should not be cas9, a nuclease, to edit genes. A smaller nuclease is needed to complete the task of cutting off a DNA strand, and then the reverse enzyme can edit the gene at the cutting site under the guidance of RNA chain.

At this time,

to find a brand-new gene scissors, Xu mang needs to have three characteristics: smaller, more stable and more complete.

Smaller means that it is easier to be used in clinical gene therapy that needs in vivo delivery, more stable is able to maintain high enzyme activity in a wide range of temperature and pH, and safer is less Miss target effect.

However...

this is not a general difficulty!

In fact,

in fact, Xu mang has two new RNA directed nucleases, cpf1 and c2c1, which are smaller than cas9 and easier to enter tissues and cells. In particular, cpf1 is far away from the recognition site when it cuts, which gives researchers more choices in editing positions.

However, Xu is more inclined to c2c1, an RNA directed nuclease, which is smaller than cpf1 and is easier to deliver between cells through viral vectors. However, c2c1 is thermophilic, so it is difficult to develop a useful gene editing tool.

No way,

c2c1 comes from acidophilic thermophilic bacteria and needs a certain temperature for normal operation. According to a foreign research report, its optimal temperature is 48 ℃, which can directly burn ordinary mammals to high fever.

Redesigning c2c1 temperature is a challenge for Xu mang. As long as the challenge is completed, all the following problems will be solved easily.At this time,

the mobile phone rings,

the caller is uncle.

"Hello?"

"Uncle..." Xu mang said bitterly: "yes... I'm in the capital, and I won't go back for the Spring Festival. Oh... I'll take care of myself. Don't worry about it... HMM!"

Hang up,

Xu continues to rush to solve the problem. However, only ten minutes later, the mobile phone rings again, this time from Xiaoman.

"Hello?"

"Husband... I got five catties of rare tea for my father and a necklace of more than three million yuan for my mother. Should it be about the same?" Yang Xiaoman asked, "do you want to take your relatives and friends with you?"

"Er..."

"buy some gifts for my younger brother and sisters." Xu mang said calmly: "for example," five years of college entrance examination three years simulation "," five years of high school entrance examination three years simulation "," college entrance examination must brush up "... Let these little guys do not want to live a good year

"..."

"Why are you so bad?" Yang Xiaoman said: "I'm the sister of these people anyway. Forget it... I don't want to talk to you. Make great efforts. I'll go shopping again."

"Pa,

was hung up,

Xu put down his mobile phone and looked at all kinds of information on the table, and for a moment he wanted to cry without tears.

In particular,

labor and capital are fighting with you!

......

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