Chapter 728

After dinner, Guo Xiang returned to the laboratory and received a call from Song tingshen.

"Miss Song?" Guo Xiang shouted.

"Guo Xiang, what's the progress of HIV drugs over there?" Song tingshen asked.

"No progress has been made." Guo Xiang shook his head and tried so many drugs, but the effect was not obvious. It may be the wrong ratio or the wrong dosage.

"Last time, the patient with liver cancer had an AIDS outbreak. It may be because the body's resistance to surgery is weaker, and the immune system will not work as soon as it is attacked. Now there are symptoms of persistent fever and swollen lymph nodes, and there is a red rash on the body. " Song tingshen said.

"That's the disease." Guo Xiang frowned. "You can let him take the medicine first. Although our combined medicine hasn't come out yet, ordinary medicine can still be taken first."

"Then we have no way. There is no department for this disease in our country, and there is no medicine. We can only let him return home for treatment." Song Ting sighed deeply.

Guo Xiang nodded. There was really no way. Although they had drugs in their laboratory, they were also used for experiments. They were not the place to see a doctor, and there were no other treatment equipment, so they couldn't help him.

"Then let him return home. There's no way." Guo Xiang said, "I also need to speed up the progress and do it earlier."

Song tingshen hung up and could only tell the patient the truth. There was no way to treat him. It was useless for him to be hospitalized again.

The patient also understands that he has gone through the discharge procedures. He has lived in liver cancer for more than a month, which is also the time to discharge, but he is in such poor health that he is likely to relapse, but there is no way. No one can control it.

Guo Xiang told Li Yuanhang about the patient. He nodded, "we can only control the medication first. Let's wait until the time of drug resistance. We have to speed up the progress."

Guo Xiang nodded, looked at the data in the computer and took a new group of prescription drugs to the mice.

The medicine was mixed in the rat feed and was about to be fed to the mice. Guo Xiang noticed that some mice who had been suffering from AIDS were still very energetic and some were in poor spirits.

She suddenly realized a problem. Western medicine is generally fixed, but it will be distinguished according to people's age.

For example, if adults take three pills at a time, children will halve and take one and a half. This is generally the rule.

The experimental mice are small and usually recalculate the dosage according to their weight.

For example, some infants will also calculate the medicine according to their weight. How many milliliters to eat within a few kilograms and how many milliliters to eat above a few kilograms.

But they are not divided according to the severity of the disease.

If it is Chinese medicine that can do this, Chinese medicine generally makes pulse diagnosis and prescribes medicine according to everyone's physical differences and different conditions.

Therefore, the prescriptions and dosage of each patient may be different, which is one of the reasons why traditional Chinese medicine can not be popularized like western medicine.

However, the severity of AIDS is very obvious. Some may not carry the disease. Only some of them are heavy. All kinds of symptoms appear. Some of them are light. So can they use the same medicine and the same dose?

Should it be divided according to people's constitution and condition like traditional Chinese medicine?

Guo Xiang suddenly felt that his idea was right, because HIV attacks the human immune system.

Maybe most people have only a very vague concept of the immune system, and they don't know what it is.

In fact, the human body is a very sophisticated system, with its own defense forces against foreign invaders.

These defense forces are many immune cells. For example, lymphocytes are immune cells against infection and tumor. The most important ones are Th cells containing CD4 molecules and TC cells containing CD8 molecules. In other words, T cells are the defender of disease resistance.

CD4 cells are equivalent to sentinels and play the role of "informer". CD8 cells are combat forces and can kill infected cells and cancer cells.

When HIV enters the body, it infects the surface CD4 cells, which makes CD8 cells unable to kill infected cells and cancer cells, causing opportunistic infections and cancer.

Therefore, once people are infected with HIV, CD4 cells will decline progressively or irregularly, indicating that the immune system has been seriously damaged.

Generally, the CD4 cells of normal people are 500 ~ 1600 per cubic millimeter, which can be detected by blood sampling.

Therefore, the CD4 cells of these mice may be different, and the drugs and dosage should be different.

Guo Xiang suddenly realized that they might have done useless work in the previous month.

She immediately called Li Yuanhang over and said her thoughts.

Li Yuanhang listened very carefully and nodded as he listened. "It's probably so."

"Didn't you consider this when you were in the United States?" Guo Xiang can't help the problem. They have studied it for so many years.

"I entered the research room relatively late, and CD4 cells were also measured there, but I still used single drug at that time. Now I didn't think of this in combination." Li Yuanhang said.

"I think our previous idea was wrong. We should use drugs separately according to the number of CD4 cells in each mouse, so as to have an effect." Guo Xiang said.

Li Yuanhang nodded, "yes, we've tried so many drugs before. It's impossible to have no effect. This should be the reason. There's no symptomatic!"

"Now we will test the CD4 cells of each mouse immediately, then adjust the dosage and dosage." Guo Xiang said decisively, "there are 500-1600 CD4 cells in normal people. Setting more than 500 is a safe value. It may be positive, but within the safe range, it is still a carrier."

"0 ~ 200 has been very serious, with complications, which is a severe patient; 200 ~ 500 are mild patients. Although they are ill, their symptoms are not serious. " Guo Xiang continued, picking up the previous record book, "then we also divide the medication into groups, tenofovir, zidovudine and lamivudine, and yifeiviren, nevirapine and Coriolis. We use different drugs according to the symptoms of different stages."

"OK, we'll re test it right away." Li Yuanhang nodded. At the same time, he admired Guo Xiang. He didn't think of these.

The two men began to draw blood from the mice and test them in flow cytometry. These equipment were bought from the United States.

Then give each mouse a number, indicate the number of CD4 cells, and then use different drugs and doses.

Both of them were a little excited and had a hunch that they might succeed this time.

After all the work was done, the two cleaned up the laboratory and disinfected the console before they left the laboratory, took off their protective clothing and put on a white coat.

Guo Xiang suddenly found Gu Zhennan standing outside the office window.

She opened the window. "Why are you here?"

"What time is it? You don't look at the time. I thought something had happened to you. " Gu Zhennan complained a little.

Guo Xiang noticed that it was dark outside. Looking at the clock on the wall, it was more than eight o'clock. He was surprised, "it's so late?"

"As soon as we did the experiment, we forgot the time." Li Yuanhang smiled and looked at Gu Zhennan. Should this be Mr. Guo's lover?