Chapter 1518

"Professor." Huang Mao knocks on the door and enters Yang Rui's office.

"Oh, Huang Mao, what's up?" Yang Rui rubbed his temples and was still immersed in the tiredness of continuous telephone communication.

It is not a simple matter to change the test items of a new drug. Many new drugs will try to add new indications after they are sold. However, if a new drug wants to change the indications before it has passed the clinical trial, it is a failure.

FDA New drugs that fail to be reviewed will only be treated more harshly.

Most of the time, it is not approved.

Historically, Pfizer also spent a lot of time in order to replace sildenafil's indications. It took more than half a year and inexplicable cost to let FDA relax.

Compared with the scale of the United States, if a scholar starts to do experiments at the age of 40 and saves data, it will be a big move. When he reaches the age of 50, the data he saves is just eligible to contribute to science. Whether he can publish or not is still a different matter.

Science aims at the whole field, but everything in the scientific field, from traditional physical chemistry, popular computer hardware and software, rare paleontology excavation and Egyptian character research, is qualified. It is the most extensive one in CNS. It can be said that everyone has the hope of Publishing Science except the pure liberal arts projects involved by liberal arts monks.

The number of contributions per year, from the perspective of papers, is also an astronomical number.

Fortunately, only 100 papers are published every year. The probability is so low that most scholars regard it as good luck.

Only Yang Rui can hold down the G-spot of science.

The title of Nobel laureate is only one aspect - but it has to be said that it plays a very important role, especially for young and active Nobel laureates, whose articles must be attached great importance from the moment they fall into the hands of editors.

The particularity of sildenafil, especially the popularity of nitric oxide related topics, has brought more recognition.

If there were no additional changes, by 1992, nitric oxide would have been named molecular of the year by science.

In recent years, the topic of nitric oxide has been too hot.

Any relevant research will be looked up in any journal.

Not to mention nitric oxide from Nobel laureates.

Sildenafil can harden the corpus cavernosum by stimulating the body to release nitric oxide.

From this point of view, Viagra is to inflate yourself.

What science wants to publish is the inflation process.

Pfizer may be very good in business, but they can't and don't need to make science obey.

Sildenafil was just a useful compound screened out by a commercial company. Although it sold more than 180 million US dollars, in the eyes of the scientific community, sildenafil may not have been "favored by Yang Rui".

The chemists in charge of the clinical trials of sildenafil are only the world's fourth-class scientists - the first-class Nobel Prize, the second-class Nobel Prize, the third class lectures in famous universities, and the fourth class life-long professors - although the fourth class scientists are world-class in the eyes of the public, science has never been in the eyes of the public.

However, when the world does not say whether the journal itself can firmly abide by it in front of Nobel laureates, the resources of high-end scholars will be enough to break through this barrier.

As long as the word "sildenafil" appears in the paper, you can think of Yang Rui for the first time.

The news that he spent 180 million on Pfizer has not been hidden. Anyone who cares about the scientific community can hear more or less, especially the relevant circles. Besides, peer review is not a closed book examination, and reviewers also need reference materials. No matter what posture they use, it is impossible to Miss Yang Rui's news.

The news that "Yang Rui has made new achievements" spread out before the publication of the latest issue of science, forcing science to schedule it as quickly as possible.

The whole process, Yang Rui do not have to take the initiative to promote, it is easy to complete.

When people from greenstone corner went to FDA with science, in fact, FDA scientists also received the news.

For pharmaceutical companies, the FDA really exists like a God. It is not too much to kill or take. Especially after the 1980s, the authority of the FDA can be said to be extremely powerful.

But the FDA is not immune.

Its lifeblood is science.

FDA Their independence and authority are based on science. Most of the scientists who serve them are famous experts in the industry.Of course, these people can stick to their own opinions and make decisions, just as Yang Rui did to LV Bo on that day. However, in the face of scientific problems, their independence has to be shaken.

The scientific questions raised by ordinary scholars, of course, can not shake the FDA experts.

However, if they are indifferent to the demands of Yang Rui, the Nobel laureate and scholar in the active period of scientific research, their fame and independence will be greatly reduced.

Bureaucracy and procrastination are not allowed when replying to the documents submitted by Yang Rui.

The only reason they can refuse Yang Rui is science itself.

This is also the reason why pharmaceutical companies hire Nobel laureates after the 1990s. However, few pharmaceutical companies can really hire Nobel Laureates in the active period of scientific research.

The Nobel Prize in medicine and physiology is given to three people at most every year, and many of them are given to the old man.

Young and middle-aged scholars have a low chance of winning the Nobel Prize. Few of them are willing to give up scientific research and go to pharmaceutical companies.

Even Yang Rui, who works as a part-time laborer in sildenafil, would not have done his best if it had not been for the amazing profits of Viagra, which can save him time to make money, increase scientific research funds, change a drug, and win the Nobel Prize.

For the world's first-class scientists, time is the most important resource, and money has long been unimportant.

Instead of talking about the importance of money, it's better to talk about the reality of social wealth - anyway, they take money according to the proportion of GDP.

Sildenafil's requirement to change its indications has passed the FDA's approval faster than in history. Science has published all of them. Against the mainstream scientific community, it still needs courage.

This time, the FDA didn't show it.

For Yang Rui, it's hard to do the whole thing. For Huang Mao, who is in charge of the clinical experiment, it's pressure.

"Professor, this is the list of volunteers for clinical phase II." Huang Mao lowered his head and put a thick book on the table, making a sound of Dong.

Yang Rui took a look and frowned: "you made a mistake."

It's not. It's a thread bound hardcover book. It's all used to write names

"There are twenty-seven thousand four hundred and twenty-seven." "Obviously unsuitable volunteers have been eliminated," Huang said

"27427 people, it's a bit too many..." Yang Rui guessed that many people would come to sign up, but he didn't expect so many people.

"It's more than just a lot." Huang Mao could not help but Tucao: "I checked the literature. This kind of clinical experiment abroad is usually a few hundred people sign up, and more doctors make complaints about it."

The recommendation of licensed doctors is very important for clinical trials of pharmaceutical companies, especially for phase II trials. The safety problem has not been completely solved. No trusted doctor tells you that this is the most appropriate choice. On the premise that only a few people can know the project, let alone sign up.

"Do they know what clinical phase II means?" Yang Rui couldn't help saying, "we just made a mistake before. Do they know the danger?"

"I guess I do." Huang Maodun for a moment, said: "the problem is not how many people they have, I can also select a large number of people, you see the identity of these people."

Huang Mao opened the thread bound hardcover book to a corner and saw a string of conspicuous work units and names behind a person's name.

That's the name of a whole page.

"Good guy, you don't have to wait in line to fly." Yang Rui sighed.

Huang Mao turned his eyelids. It can't be said that Yang Rui was wrong.

"Now what?" Huang Mao asked: "some people have called, I answered two, quickly pulled the phone, you did not receive the phone?"

Yang Rui Leng for a moment, said: "I am not in the clinical experiment center these two days."

Jingling.

Just then, the phone just hung up rang again.

Yang Rui hesitated for a moment, but he picked it up. He said twice, "I understand what Mr. Li said. In this way, I'll ask Huang Mao to see what his arrangement is."

With that, Yang Rui hung up and decisively pulled out the phone line.

Huang Mao stares at Yang Rui with his bright eyes.

Yang Rui shrugged his shoulders, pointed to the thick book and said, "this is more famous than the people in the book."

"What about..." Huang Mao also helpless: "really can't, we all give arrangement?""You're kidding. If something goes wrong, you're a rare massacre." Yang Rui said no. The so-called human life is of vital importance. Although he knows sildenafil is OK, what is the loophole between the two?

As a scholar, do the second phase clinical, make the scale of tens of thousands of people, even if successful, it is also a joke.

"If that doesn't work, let's apply for the provincial drug approval at the same time." Before Huang Mao came to Yang Rui, he had already thought about it.

……