Chapter 1506

Pharmaceutical companies are very headstrong in Jinyuan world. If Yang Rui is a Chinese American or something, let alone talk about business with Pfizer, he will have to thank Lord longen if he can be recruited by Pfizer.

If not, it's a group of lawyers who rush up and make you lose money.

Now, Yang Rui is the director of ion channel laboratory, the owner of Huarui laboratory, Yang Rui genetic engineering laboratory I, the inventor of PCR, the pioneer of human gene era, the king of G protein coupled receptor, the breakthrough of ion channel, the Nobel Prize winner, the real king of genetic engineering, and the master of bovine embryo, Chinese medical standard setter, pioneer of 863 program, rescuer of millions of patients with arrhythmia, male god of Chinese and foreign media, father of cloned sheep, terminator of thalassemia, expander of coenzyme Q10, lightning rod of Chinese scientific community, supreme monarch of 64 experimental dogs

As a pure Chinese and a Chinese scientist, Backed by the big tree of China, he can fight every minute for foreign enterprises and state-owned enterprises to doubt life together. He can also formulate policies to make pharmaceutical companies that want to develop in China look up at the starry sky and lament the injustice of the world.

Being a big boss in China, a closed and huge market economy country, has such advantages. Unlike Japan, South Korea and other countries, if they want to implement a drug closure policy, they have to consider the implementation of security regulations.

If you want to say that, how strong is the strength of pharmaceutical enterprises, especially Jinyuan? It goes without saying that it is common to influence the policies of other countries. In order to make money together with insurance companies, they can change their health insurance policies and make people die.

However, China has never been a normal country.

Even without Yang Rui's intervention, Pfizer will encounter many problems in China. For example, the name "Viagra" was snapped up by domestic enterprises. As a result, after years of litigation, there was no result. Until the end of the patent period, Pfizer could only name it after Viagra.

Pfizer's problems don't stop there. After the expiration of Viagra's patent, domestic Jinge raised the banner of competition. In addition to advertising, their most ruthless move was to enter the prescription drug industry.

For quite a long time, Chinese people who want to buy Viagra need to issue a prescription to buy it, while Chinese people who want to buy Jinge can get what they want if they go to any small drugstore with money.

Is the competition fair? At least at the policy level, this is the result of competition.

Whether a drug can go on the market, whether it should be included in the list of prescription drugs, what special requirements it has, whether it can be produced in China, whether it must be produced in China, and whether further tests and clinical trials should be conducted are ultimately decided by the leaders of various committees.

Facing a market with 1.2 billion people and an average annual growth of more than 10%, Pfizer is not willing to offend the big guys.

Even, in order to make up for the relationship, Pfizer also invited a China expert to China to discuss with Yang Rui.

"Frankie? How do you come here on behalf of Pfizer and stop working at Jericho? " When Yang Rui saw the representative of Pfizer, he was stunned for a few seconds.

He hasn't seen the British big fat for a while.

Frankie laughed like a cracked doughnut and said, "I've opened a special consulting company to provide services about China for pharmaceutical companies, and my income has increased several times."

"You're your own boss? That's great Yang Rui gave his thumbs up to his old acquaintance, comrade Frankie.

He likes this fat Englishman very much. Compared with the common arrogant and prejudiced foreigner nowadays, Frankie is much more sensible and has better communication.

Frankie can eat this bowl of rice, it is to rely on everyone's love for themselves.

Seeing that Yang Rui agreed with his choice, Frankie was so happy that he used the Chinese he had just learned, cocked his tongue and said, "it's all up to my brothers!"

Yang Rui laughed, nodded at Frankie and said, "with your hard work in learning Chinese, I'll invite you to dinner. Well, go to my lab. I'll let Mr. Yu handle it. "

"Chef Yu's skill is three-star." Frankie said it and became greedy. He said Michelin 3-star was at its peak.

"Yes, you've had a meal made by chef Yu. That's good. No introduction. Would you like to order?" Yang Rui shows Chinese hospitality. He is not in such a mood for a strange foreigner.

"Chef Yu, please." Frankie said, pausing for a moment, and said, "if you can, stewed lion's head, I'd like two."

"Well, there are two big fisted stewed lion heads. The rest is for chef Yu to choose. There is one..." Yang Rui looked at Frankie's broader figure and said, "there are seven or eight dishes. They should be almost the same. They should be bigger."

Frankie listened to the translator's whisper and nodded: "large, large is good."Neither of them had the intention to talk about business, but Pfizer's manager, Connell, was very happy, thinking that the six figure expenditure was not in vain.

As chef Yu is getting older, he has less time to cook in person, but more time to think. The dishes he makes taste better.

However, most of the dishes were made by his apprentices.

It is said that he is an apprentice, and now he is a chef. Outside, he is also a celebrity in the kitchen industry. Whether it's frying or cooking, he has his own characteristics.

For example, Frankie's favorite stewed lion's head, the traditional method is to slice the pork ribs into pomegranate seeds with a flat knife. The best proportion is fat seven and thin three. However, chef Yu's second apprentice has begun to consider health factors.

His lion's head is not as fat as master's. He uses the ratio of fat to lean and skims oil with ice water. It not only keeps the tender and smooth taste, but also increases the proportion of lean meat, making the stewed lion's head healthier and more suitable for people who don't lack meat.

Of course, there's no way to talk about eating too much because it's delicious.

As for whether it is authentic or not, Yang Rui has long been indifferent.

Modern people eat famous dishes, the pursuit of authentic mentality is the most unorthodox. Authentic can only be said to be in line with the taste of a generation. If not, it is in line with the taste of a literati poet. It's the worst. It's also in line with the preferences of people in a region. There's still a long way to go for delicious food.

From this point of view, eating authentic food is equivalent to queuing up for a tour and taking a group photo at the entrance of the scenic spot. It's for the circle of friends.

"Professor Yang, how did you think of buying sildenafil?" When Frankie couldn't walk, he leaned back in his chair, touched his stomach with his hand, and asked with a smile.

"I'm optimistic about the future of nitric oxide drugs." Yang Rui did not hide his approval. He took a sip of wine and spoke slowly.

Sildenafil is an active drug that has been tested for animal safety. No matter how cheap it is, it costs tens of millions of dollars. If it is not approved and optimistic, there is no reason to buy it.

Nitric oxide is also the most popular drug type in the past two years. The so-called nitric oxide drugs, the most famous of which is nitroglycerin, is the explosive ingredient of Nobel Prize. It also has a miraculous effect on angina pectoris, but for hundreds of years, people do not know why.

It was not until the end of the 1980s, that is, in the past two or three years, that the biological community slowly understood that nitroglycerin and other organic nitrases could increase the concentration of the second messenger in human tissues, and the way it produced effect was to metabolize nitric oxide.

This is a brand-new signal transduction mode and a deep understanding of human self.

The term nitric oxide has become very popular. In a few years, it will even win the Nobel Prize.

Pfizer also carried out sildenafil research. They screened a large number of molecules and finally selected this small molecule compound named uk-92480.

We can see from its name and label that it takes a lot of trouble to sieve out a molecule.

Although Yang Rui believes that there must be other molecules that can play a similar or stronger effect, it's really not possible to screen them out by giving him tens of millions of dollars or even hundreds of millions of dollars.

Pfizer is reluctant to put it on the shelf for this reason.

Nitric oxide drugs have just become popular. Now they are sold, and it's not easy to screen out a usable one, which is as safe as this one.

However, China is also a big market that has just been booming. Pfizer is unwilling to find a big obstacle for itself as soon as it opens the door.

French, who had Pfizer's money, naturally wanted to speak for Pfizer. He also drank a Baijiu, a spicy and bare teeth, and then said, "why do you see sildenafil, or is it not? Isn't that what Pfizer is asking for? "

On the surface, he is speaking for Yang Rui, but in fact, he is raising the price.

Pfizer is still reluctant to sell. At this time, Yang Rui forced it out to talk. The first choice is to set a sky high price.

Yang Rui was not surprised, holding a glass, said: "I choose sildenafil because it is the safest drug in nitric oxide. Huarui's first drug, not to mention its efficacy, needs to pay attention to its safety. "

"Eh, is this the direction of your enterprise?" Frankie was taken askew by Yang Rui.

Yang Rui nodded and said, "yes. OK, let's talk about Pfizer's offer. "

"You are in such a hurry, don't you ask people to charge you a high price? Why not Frankie did the same thing.

Yang Rui leaned back on the chair, put his hands on the side, with a big man's expression, and said, "let's have a try.""This..." when frankieton was shocked by Yang Rui.

His task is very simple. He contacts Yang Rui, relaxes the relationship, and gives an offer. If he angers Yang Rui, damages the Chinese market, and Pfizer is unhappy, he will be blind.

"Come on, Cornell." Frankie quickly found a scapegoat.

Pfizer's manager didn't care. He didn't know Yang Rui and didn't establish any relationship. After hesitating for a few seconds, he said, "if we only sell sildenafil in the Chinese market..."

"There is no such sale. What you are holding now is a compound, not a compliant drug. Have I developed a new drug, Only in China? Am I crazy? " Yang Rui immediately interrupted Connell.

If a new drug is successfully developed, it will cost hundreds of millions of dollars. There is no reason to sell it only in one place.

If it can cure the disease of aliens, pharmaceutical companies dare to invest money to restart the Apollo program.

"You can give us the market outside China..." he said with a smile

"Agency sales is the future. Now let's talk about the trading of compounds." When Yang Ruizhen wanted to sell the small blue pills, he still needed foreign pharmaceutical companies to act as agents, but that was later. It was meaningless to talk about these before he saw the efficacy.

Cornell said casually. He looked at Frankie and said, "we have spent hundreds of millions of dollars to develop sildenafil..."

"If you amuse me, there's no need." Yang Rui suddenly stood up.

"Professor Yang Rui, how about our cooperative development? If you are interested in sildenafil, we are willing to cooperate with you in an open scheme, which can be very open. " Connell's desperate hint.

For Pfizer, the temptation of Nobel Prize winners is also very great.

In particular, Yang Rui, who has a successful precedent in developing new drugs, is a leading biologist who has made G-protein coupled receptor. His qualifications are better than those of the current leader of sildenafil, treet. It can be said that as long as Yang Rui is willing to cooperate and the terms are not too harsh, Pfizer is very interested.

Even if he didn't make any achievements, sildenafil's new drug might be sold for hundreds of millions of dollars as a Nobel Prize winner.

That's the biggest reason Frankie gets six figures.

He immediately said, "Professor Yang, this is a rare opportunity. You can put forward whatever conditions you have. Sildenafil has just done animal experiments. It's still a long way away from the market. You may sell it then. Why don't you start to cooperate now? "

Desferridone belongs to a long-term recycling project. Yang Rui was too lazy to spend time on it, so he sold it in a milestone way.

Even if Viagra wants to cooperate, it is also after discovering its real efficacy.

"Find someone who can make a decision and ask for a price." Yang Rui was not affected at all by Frankie's words. He said, "I can offer a high price. Otherwise, I will buy other kinds of nitric oxide compounds. If I develop them first, the value of sildenafil will be greatly reduced."

The greatest value of a new drug lies in its new mechanism to treat diseases.

In other words, in the past, patients with poor tolerance to certain drugs may be more suitable for taking new drugs. New patients represent higher sales.

Naturally, if there are similar drugs on the market first, the later drugs will inevitably be affected. In particular, according to the rules of the FDA of the United States, the efficacy of the later marketed drugs should be compared with that of the first marketed drugs.

If the efficacy is equal or inferior, the later developed drugs can't even go on the market. For a company, the stock price will be hit hard enough.

It's a business decision worth hundreds of millions of dollars, something Connell can't do.

He immediately bowed his head and said, "I'll inform the company headquarters immediately."

After that, he said in a small voice: "Mr. Yang Rui, I hope our negotiation will not interfere with Pfizer's business in China..."

"Of course it interferes." Yang Rui is not a little white rabbit, calm way: "can't make the correct business judgment of the company, is not good business, you can quote Pfizer leadership."

"Professor Yang, here's to you." Frankie's not convinced.

The more aggressive Yang Rui is, the more he likes it. Pfizer can't give up the market of one sixth of the world's population. Yang Rui's pass is what they have to pass.

Frankie just felt that his consulting company had a lot to offer.