Chapter 1206

Su xiankai became more and more proficient and soon became an expert in bovine rhodopsin.

In fact, this is the life of the laboratory. When the laboratory just started to decide what to do, most of the participants actually blacked their eyes and could only learn while doing in the later research.

This is probably different from what ordinary people think, or in other words, from the industrial and political life.

Repetition is about one of the most common ways of working in industry and politics. For example, in a private enterprise, the staff he wants most are experienced staff. What kind of experience? Have done so and so project, or familiar with so and so work, so as to facilitate repeated experience.

But in academic circles, this is not the case.

In addition to some small laboratories or individuals who have been working on certain projects for many years, the requirements of academic circles to expand, or to open up new fields, are much higher.

Therefore, most academic researchers are in a state of lifelong learning and constantly trying new projects and new jobs.

This is even more true for more advanced laboratories. What they do is not always cutting-edge science, but something new. Some of these things are familiar, but some are rare.

Learn to do it when you are out of the ordinary, read books or do experimental training by yourself, and finally do it well. A project may end, and then recycle and repeat.

Su xiankai has never made bovine rhodopsin before, and there is not much in the world. If you want to learn, there is no place to learn. It's good to teach two or three kinds of protein in the school. If you teach every kind of protein, you don't have to worry about whether the textbook can be compiled, and you don't have a life span of 800 years.

However, it's the most common situation that you have to do something without learning.

One of the effects of repeated experiments is the high efficiency of learning. If it is a backward follower laboratory, it is the most cost-effective to train soldiers through various repeated experiments.

Of course, there is a direction to ponder and learn.

Without Yang Rui's limitation, Su xiankai would prefer to study bovine rhodopsin itself and understand its working mechanism and function.

However, Yang Rui's orders are simply boring.

It's always about simply increasing production.

Double that.

Five times.

Ten times, the order still increased production.

Su xiankai's research direction can only increase production continuously.

For biologists, increasing production has never been a mysterious topic. The smaller the unit, the more so. For example, penicillin is often used as an example. In the early 1950s, the output of penicillin in China was dozens of kilograms, so that the price of 200000 units of penicillin reached the level of one or two gold. By the 1980s, what was the output of penicillin in China? Hundreds of... Units are tons. The price for patients has also been reduced to 10 cents a bottle.

No other, penicillin production is caused by the upward growth of the rolling.

Bovine rhodopsin is essentially the same as penicillin.

Even the coenzyme Q10 that Yang Rui made at the beginning is very similar.

Once upon a time, when Yang Rui was in Xibao meat factory, the production method of coenzyme Q10 was tissue extraction method, that is, to make some pig heart and cow heart to be mixed and broken, and then extract the desired coenzyme Q10 by various means.

Later, including Xibao meat factory, the scheme was improved and the plant extraction method was adopted, which greatly reduced the production cost. The later semi microbial extraction scheme, even the total synthesis extraction scheme, was also a choice with the progress of technology.

At present, there is only one method of tissue extraction for bovine rhodopsin.

However, compared with products such as coenzyme Q10, research materials such as bovine rhodopsin need not be too costly.

Su xiankai asked for an increase in the supply of fresh ox eyes, and at the same time began to slowly change the solution used for extraction, and even take RE Extraction measures... Speaking of the specific details, naturally it is very complicated, but in essence it is quite simple, similar to factory oil extraction, one is to increase the total amount of extract, the other is to reduce the loss.

Moreover, just like the refining process of extracting oil, the purification process of bovine rhodopsin is also needed.

It took Su xiankai about a month to get into the fast lane.

The increase in output has also increased from 10 times to 50 times.

In this way, the ion channel Laboratory of Peking University has officially entered a node - the output of raw materials has finally exceeded the consumption.Gu Qiang, fan Zhenlong and Wang Sisheng, together with two research dogs, were busy, but in the end, they could not consume so much bovine rhodopsin.

In this regard, Yang Rui naturally won't let it go lightly, and forced him to order: "this week, we will give you a buffer time. Jiajiaban will use the bovine rhodopsin made by Lao Su's group. From next week, I hope you can think of a better way to speed up the experimental process."

The faster the experimental process, the greater the consumption of raw materials. Of course, there are some heretical ways, but in such a small laboratory, there is no such way.

Fan Zhenlong bitter face, said the baby can't do, or give the baby extra.

Yang Rui said without sympathy: "the only way to increase manpower is for the group with better performance. The progress on your side is obviously slow. This can not be solved by increasing manpower. On the contrary, you have to find ways to improve efficiency."

Gu Qiang, fan Zhenlong and Wang Sisheng are two research dogs, so they have to work overtime to figure out the way.

However, their overtime, in any case, is not as good as Su xiankai.

In order to achieve 100 times of production capacity, Su xiankai has long been freed from the 110 hour working system. He works more than 130 hours a week. Occasionally, if he only works 15 hours a day, he will be too excited to sleep.

When the output of raw materials came up, the follow-up experimental group had to keep up.

G Finally, the conformation of the transmembrane region of protein coupled receptor has been gradually improved.

To get a high-resolution three-dimensional structure, that is, the three steps.

The first step is to have a conformation.

Conformation is an exclusive term in organic chemistry. It is a high-end version of hydrogen dioxide. In space, it indicates where the hydrogen is, where the oxygen is, and the angle between each other.

The second step is to obtain the crystal structure.

The third step is to get high-resolution 3D structure.

Any of these three steps is a CNS level achievement that can cause a sensation.

In fact, except for Yang Rui, the goals of other international laboratories are only one step.

No one wants to complete three steps at a time, or even further study the signal problem.

Because of these three steps, except for the first step, which is a little reluctant, each step is a result that may win the Nobel Prize. Who will give up such a huge temptation and secretly study the next step?

However, there is no doubt about the temptation to get three conclusions.

Assuming that the Nobel Prize is awarded to the three-dimensional structure of GPCR, those who are qualified to take the stage to receive the prize should include those who complete the crystal structure of the second step, those who complete the three-dimensional structure of the third part, and those who complete the subsequent signal transmission. If one of the three completes the first step at the same time, it will undoubtedly become the first prize winner, If Sany is completed together, it is possible to win a prize alone.

Of course, since the 1970s, there have been fewer and fewer Nobel prizes awarded alone. In order to meet the number of three people, they have even tried to bring two unrelated achievements together to give prizes.

The number of people who are really eligible for the Nobel Prize has greatly increased over the years.

However, GPCR is still the most powerful field. If anyone can win the Nobel Prize alone, it can only be such a project.

Although Yang Rui knew it was unlikely, he still didn't want to give up at the beginning.

After all, foreign laboratories have not yet made efforts. There are still some opportunities in the ion channel Laboratory of Peking University. Even if they are very small, they can still be called opportunities.

Moreover, if it is very small, the conformation of GPCR is very small, let alone the following steps.

……