Chapter 918

Anyone who comes to lobby Yang Rui is ready to go back.

At worst, the mode of "I don't listen, I don't listen, I just don't listen" can be opened.

However, Yang Rui could not even listen to Professor Cai's words.

He will stay with his own Cao Baoming and Wang Guohua and let them stroll in the laboratory. Yang Rui invites Professor Cai into the office.

Professor Cai did not hide his purpose. He sat down and first mentioned Jingxi general pharmaceutical factory. Then he talked about Jingxi general pharmaceutical factory's investment in biological experiments over the years. Then he changed the subject and said, "Jingxi General Pharmaceutical Factory is going to be unable to sustain. They used to produce tablets and powders, but now factories in the south are opening one by one, The selling price is even lower than their cost, robbing all their old customers. Qin Hanchi's medicine as an agent for Sanmu is a last resort. If it fails, the thousands of workers in Jingxi general pharmaceutical factory and the raw material factory that supplies them will be in trouble. "

"Do you know Qin Hanchi?" Yang Rui asked.

"Yes, but this time Lao Zhang sent someone to me." Professor Cai then explained: "Lao Zhang is from the GMP Preparatory Committee. He also supported by election before. In addition, several old friends from the Ministry of health also called."

When Yang Rui ran projects and achievement appraisal with Professor Cai before, he saw that Professor Cai has a wide range of contacts, but on the other hand, a wide range of contacts means that he has to bear the cost of making friends.

Yang Rui nodded silently and continued to listen.

Seeing this, Professor Cai said, "if you have any ideas, just tell me. If you can tell them, I'll tell them. If you can't, let's discuss."

Then, Professor Cai laughed and said, "although I'm here to help Qin Hanchi speak, I can also help you speak."

Yang Rui wry smile: "how everyone thinks I have ulterior motives."

"Yes?"

"I asked them to supplement the safety test because I didn't trust the drug Yang Rui said helplessly: "the research report published by lvboding is not enough. It is risky to produce and promote lvboding in China rashly."

"Is it more risky than Chinese patent medicine?"

Yang Rui is speechless. In this discussion, he and Professor Cai are not of the same order of magnitude.

After thinking for a moment, Yang Rui said: "the scale of use of lubodine is larger than that of Chinese patent medicine. In addition, in the design of lubodine, it is designed to take medicine for a long time. Therefore, if there is a safety problem, its risk will continue to accumulate. I think it is not wrong to be more rigorous."

Professor Cai looked at Yang Rui for a while and suddenly said, "it's not like your style."

"What's my style?" Yang Rui is a fool.

"Never move forward." Professor Cai gives his own answer.

Yang Rui recalled that when he was working as a potassium channel, he did not move forward. PCR is relatively simple, but the follow-up lawsuit is several million, and he doesn't want to compromise at all. He has to work hard, and the subtext of "going forward" is a huge risk.

Yang Rui is rather ashamed. If you think about it like this, he really has some problems of "one time and another".

"When you talk about me now, isn't my reputation very good?" Yang Rui brushes his face a lot, and he can guess how people think of him.

When "one time, another time" is linked with power, there will never be any good words.

Professor Cai nodded and said: "the scale of Jingxi General Pharmaceutical Factory is also in the front row in the whole country. Qin Hanchi has been a factory director for nearly ten years. He is not a bad man. "

"I don't want to be a bad person," Yang sighed

"Let Jingxi General Pharmaceutical Factory pass."

"There's something wrong with the law." Yang Rui no longer talks around and answers directly.

Professor Cai naturally asked the question Yang Rui didn't want to answer: "what's the problem?"

Yang Rui can't answer.

As an antiarrhythmic drug, the foundation of its academic research is actually very solid. Identifying premature beat as a disease, linking premature beat with more serious heart disease, and then determining that inhibiting premature beat is beneficial to reducing the risk of heart disease - the whole academic chain is not made in one day, two days, or two people. This is an academic research which was established more than ten years ago with the participation of hundreds of scholars.

Antiarrhythmic drugs are even more than a drug, in the 1980s, almost all large pharmaceutical companies involved in them.In the past ten years, during the development of many kinds of drugs, has no one questioned the whole academic chain?

Of course.

However, academic discussion is only academic discussion after all. The most important problem is that the theory of antiarrhythmia has no fundamental defects.

Even Yang Rui can't say categorically that the theory of antiarrhythmia is wrong.

Perhaps there is nothing wrong with the theory of antiarrhythmia. In the simplest way of thinking, it is better to have a heart without premature beat than a heart with premature beat. After all, premature heart beat is always an abnormal physiological phenomenon. If it can be treated or suppressed without cost, it may be a good thing.

Therefore, the key to the problem is the safety of the drug itself.

So, how to prove the safety of legal boding?

Yang Rui is aware that the problem with such antiarrhythmic drugs as verapamil lies in their effects on electrical pulses.

But there's no reason to talk. Sanmu company has made a file cabinet to prove its safety and efficacy test.

For Yang Rui, the best way to prove it is clinical trials. Because the side effects of verapamil are hidden and take a long time to appear, ordinary clinical trials with small scale and short time are not enough. We need to find hundreds or even thousands of patients with arrhythmia to do double-blind tests. Half of them take verapamil, and half of them take placebo, It's a large-scale clinical phase I.

For Yang Rui's experience in desferridone, it will take about US $40 million to get a clear answer. It will take more than half a year. Of course, the number of patients with heart injury that may result from this is certain, and it can't be said that there will be several more deaths.

Can Yang Rui get 40 million dollars? Of course, I can't get it out. The milestone payment for desferridone hasn't been seen much. Besides, I can't get it out like this. He has 40 million US dollars and can research a new drug.

If we do not conduct clinical trials and engage in academic debates, Yang Rui's current status will not be able to compete with others.

There are also big cows in the research group that do LV boding. They have been working on this drug for nearly ten years, and they recite more information than Yang Rui. Even if Yang Rui can speak eloquently, they can't increase their ability to pass the FDA.

To be reasonable, FDA has always been criticized for its low efficiency and high requirements, but there are few cases where the audit is not strict.

There may be some incompleteness in the review of L & D, but in terms of the concealment and slowness of its side effects, the FDA has actually done well enough.

The FDA may have asked all the questions Yang Rui could raise verbally.

"The key now is not that I want to prove the problem of lamivudine, but that Jingxi general pharmaceutical factory wants to prove to me that it's OK." Yang Rui's eyebrows drooped, then quickly raised, and said: "Professor Cai, I'm sorry, I have to save your face, I have to be responsible for my signature."

"Even if Jingxi General Pharmaceutical Factory finds more people to put pressure on, you won't let it go, will you?" Professor Cai asked calmly.

Yang Rui nodded slightly.

"You know, Qin Hanchi didn't just come to me. In order to pass the law, the whole factory of Jingxi general pharmaceutical factory was trying to find a way. And... "Professor Cai lowered his voice and said," they have plenty of reasons. "

"I know."

"Are you not afraid?"

"I'm scared. I'm scared to death." Yang ruixiao is extremely bitter. If he is not afraid, how can he shout Wang Guohua and Cao Baoming over.

Even without violence, Yang Rui is not sure how long he can carry it. As the saying goes, it's only in Beijing that we know about the official school. Taxi drivers in Beijing can know a cadre at the department level. Qin Hanchi himself is at the department level. What level of cadre can he contact?

Yang Rui doesn't live in a vacuum.

However, Yang Rui asked himself that he might not be able to completely stop LV boding, but it would be good to delay one more day. When LV boding entered China one day later, the number of Chinese people affected by it may be tens of thousands less, and some people may survive. Moreover, many people will certainly be free from the risk of heart injury, so that they may live for several years or even more.

What's more, the delay in production of Jingxi general pharmaceutical factory may also reduce the supply of rubicin in the global market. If the supply of pharmaceutical factories is reduced, the pharmaceutical representatives will not work so hard to promote it. The number of patients taking rubicin may also be reduced, and the number of deaths may be reduced. Anyway, Americans are human beings, It's too sad to die in vain on a seriously developed drug.

Looking at Yang Rui's expression, Professor Cai inexplicably realized Yang Rui's state of mind, just as he had seen Yang Rui in Tang Dynasty centralized laboratory."It's still your style." Professor Cai breathed a sigh.

Yang Rui looks at him.

"Your style." Professor Cai pointed at him and said, "never move forward."

……