Chapter 810

Yang Rui's plan can't be more smooth after Wu Hongbo is instigated.

If we look down at the domestic biology field, we can't see that there are too many people. The biology teachers in ordinary primary and secondary schools alone don't know how many people there are. However, when we enter the scientific research field, especially when we look up, the number at the top of the pyramid is very small.

Wu Hongbo began to appear, and with such wonderful remuneration as American tourism, Huarui laboratory quickly sent out six invitation letters.

At the same time, Yang Rui continued to communicate with several pharmaceutical companies and actively communicated with Benjamin law firm.

The content of his communication was mainly about the lawsuit of PCR, and also about the price negotiation of deferoxane.

As a named partner of a well-known law firm, Benjamin filed a lawsuit with DuPont for Huarui company, not only for the lawyer's fee of $2000 per hour, but also for more business.

The landmark gambling agreement, a high-value contract, has always been a favorite of lawyers.

Landmark contracts are extremely complex, and with the existence of gambling agreements, people will pit them if they don't pay attention to them. Pharmaceutical companies, like financial companies, are born evil and can never be trusted. Lawyers are essential.

In a few days, almost all the pharmaceutical companies accepted the landmark gambling agreement model, and then began a long discussion on details. Some companies still need to consider whether to set up a joint venture subsidiary to undertake the work according to Yang Rui's request.

In fact, the cost of developing new drugs is too high for some medium-sized pharmaceutical companies to bear independently.

The average development cost of clinical phase I is US $1 million, and the requirement of milestone is US $1 to US $55 million, which means that pharmaceutical companies may have to prepare a budget of more than US $56 million for this purpose. Although they can't give Yang Rui as much as they want, they still have to prepare the budget to be qualified for competition.

The average development cost of clinical phase II is US $20 million, and the milestone requirement is US $20 million to US $60 million, which means that pharmaceutical companies may have to prepare a budget of more than US $80 million for this.

The average development cost of clinical phase III is US $100 million, and the milestone Yang Rui required is US $30 million to US $90 million, which means that pharmaceutical companies may have to prepare us $190 million for this.

As a milestone project, the maximum budget of the whole project may reach 330 million US dollars, which is not cheap in any case. That is to say, if you want to pay back the money, you can cut one-third of the budget at most, and the final cost is still $200 million.

This is actually the average development cost of a common drug.

Of course, the pharmaceutical company's cost of $200 million is a phased expenditure, which also means that Yang Rui's income will also be phased.

The easiest place for him to get money is the milestone of clinical phase I. as long as the safety clinical trial is passed, he will get less than $10 million or $20 million, and more than $40 million or $50 million. As long as the contract is signed, the money will almost certainly be available within half a year.

As for clinical phase II and phase III, it will take a long time. If the pharmaceutical company decides to sell deferoxane directly after phase I, it may take a longer time. In fact, as far as Yang Rui is aware of the established fact, the income of the second phase may be less than that of the first phase.

Because from phase II, a lot of risks and costs are actually concentrated on pharmaceutical companies. And Yang Rui's efforts in animal experiments are mainly realized in the clinical phase I.

According to the usual process of pharmaceutical companies, it usually takes three or four years to complete the second phase of clinical work, which is slower. It's no surprise that it takes five or six years to complete the second phase of clinical work. If it is fast, it is rarely shortened to less than two years.

The third clinical stage is far away. The development cost of US $100 million is mainly caused by the scale of 20000 people. The average cost of US $5000 per person is not enough. These 20000 people are not from all over the world, but need to be approved or even introduced by doctors, and sign complex contracts before they can be carried out in batches. Only the largest marketing pharmaceutical companies can easily carry out this kind of work, and the pharmaceutical companies with a slightly smaller scale have to mobilize all of them to make efforts to start a business again.

Yang Rui's eyes are mainly focused on clinical stage I. All seven compounds in clinical phase I have passed, and he can get the most part. If he is lucky, there may be 40 million or 50 million. As for the second and third phases, the most he can take is two 30 million dollars.

Of course, the final listing will also give him a huge bonus milestone. Maybe we can talk about the scale of tens of millions of dollars, but it will take a longer time, maybe not even ten years.

"Time is the least durable commodity." Looking at the schedule given by Benjamin law firm, Yang Rui can't help feeling."For you, in the days to come, just count the money. Well, if I had known how to make money by doing scientific research, I would not have gone to law school. " Yue Ting, a lawyer in Hong Kong, gradually replaced the little lawyer who had no sense of existence in the past and became the lawyer of Huarui company. He also knew about the relationship between Huarui company and Yang Rui. At this time, he looked at the documents sent by Benjamin law firm and was even more moved.

600 It's expensive to charge us $an hour, but it's still out of reach to earn US $10 million.

Think about Yang Rui's easy success in life. Nevertheless, the debate and several court sessions between the two sides lasted for more than half a year, which aroused a lot of discussion in the industry.

As a result, Yang Rui had to pay more money to Benjamin law firm, making the lawsuit budget slowly grow to nearly $4 million.

For the Chinese, it's really an astronomical number. Yang Rui thought more than once in private that if he didn't foresee the future of PCR, accumulate enough funds and make sufficient preparations, there would be no need to fight this lawsuit.

400 Ten thousand dollars is not the final cost, and victory is not the inevitable result. Think about how depressing it would be to spend more money and eventually lose a lawsuit or settle a lawsuit.

With so much money, if you try to change it into RMB, you can get more than 30 million yuan to buy a house in Beijing. You can buy hundreds of courtyard houses and easily sell them for 10 billion yuan in 30 years.

It may not be as valuable as PCR's $3 billion, but it's much simpler.

After all, it is still necessary to pay and manage to realize the value of $3 billion. It is much easier to put the house there.

Why do Chinese enterprises not want to go to the United States to file a lawsuit? Why do Chinese state-owned enterprises prefer to suffer losses rather than protest? We can see by calculating the economic accounts. If a head of a pharmaceutical company spends $4 million to fight a lawsuit and then loses, it's really an official career. Even if we win, we will probably stop on the official road.

However, the rights and interests of PCR are wholly owned by Yang Rui. Yang Rui can only bite his teeth to sign the chequebook and pass it to Yue ting.

Yue Ting carefully checked the signature and spelling, and jokingly said, "no problem, I will deposit it in the company in Kaiman."

The offshore companies in the Cayman Islands are the superior companies of Huarui. On top of the offshore companies in the Cayman Islands, there are multi-level offshore companies to help Yang Rui control Huarui and hide himself.

"Please." Yang Rui put down his pen and said with a smile: "I really didn't think about it before when I spent more than one million dollars as a lawyer."

"Benjamin's fees are high, but they are really powerful. When companies in Hong Kong file lawsuits in the United States, they generally can't get such a barrister." Yue Ting said with a smile: "recently, we'd better keep in touch. I'll report the quotations of various pharmaceutical companies to you at any time. If you make a decision, please let me know."

"Good." Yang Rui nodded: "I'm not in Peking University in recent days. I'm in Huarui laboratory."

"The scope of Peking University is too wide. Better be where there's a phone. "

"The ion channel lab has a phone, but I can't help it if I go to class or stay in the dormitory."

Yue Ting thinks deeply. From his point of view, it's really important to find Yang Rui in time. He can replace Yang Rui to negotiate, but he can't decide important issues for Yang Rui. If it takes a few hours to find someone every time, we can imagine the progress of the negotiation.

In case of another guy like Arnold, who gives an hour to decide when, Yueting doesn't know what kind of loss it will cause.

Thinking about it, Yue Ting patted his forehead and said, "can we get a pager? The pager is a bit like a telephone, but it can only call people one way. When you see the number, you know someone is looking for it. The machine is not big, and it's smaller than a slap. "

"BPS?" Yang Rui was even more surprised than Yue Ting: "now it is?"

"That's the name, you know?" Yue Ting immediately shook his head and directly answered Yang Rui's question: "I heard that Shanghai has just set up a public paging network this year, while Beijing is doing it now. I don't know if it's done well. However, some units have their own paging stations, such as hospitals and customs. I wonder if they can join the self-organized wireless paging network through people?"

Yang Rui looked at Yue ting with strange eyes and said, "you know more about technology than I do."

"I just care about things that can save time." Yue Ting understands the simple smile.

Yang Rui heart Tucao: "I make complaints about technology."

……