Chapter 805

"How do you want to bet?" Raymond was almost all over the table.

"First of all, clinical phase I. if you can guarantee the time and resources, I guarantee that there will be active substances passing through clinical phase I, otherwise, I will not have any money." Yang Rui said that the whole table was stupid.

Raymond subconsciously picked up a piece of belly, chewing and saying: "milestone payment method? Yes, but not a cent? No down payment? "

Milestone payment can be said to be a kind of payment according to the progress, but it is different from the ordinary phased payment. The milestone established in advance has no inevitable connection with the comprehensive progress or the overall progress.

This method is also often used in international projects, such as building a railway. If the payment is made by stages, such as completing one fifth of the length, the project owner will still be responsible for the whole project, although he will get the corresponding payment. Otherwise, he will inevitably suffer a claim, and the money he got before will also be paid back. However, if it is a milestone payment, the engineering party will not complete the responsibility of the whole project, and those who don't want to do or can't finish it can just turn around and leave.

Pharmaceutical companies are generally milestone payment, because no one can guarantee a drug will be on the market, let alone the sales after the market.

Yang Rui was extremely confident and said, "it's up to you to decide, I can give up the down payment, but if there are active substances in clinical phase I, I want $20 million."

"Hey, hey, brother, slow down." The Italians seemed to have been hit by F1 and cried, "20 million dollars for the first phase of clinical treatment? It's a little expensive. "

"There is no down payment for $20 million. Of course, I have no problem with a down payment of $12 million and a milestone of $6 million in clinical phase I Yang Rui shrugged.

The Italians calculated that it would be quite worthwhile to replace the $2 million milestone with a down payment, so they spread out their hands and said a word of Italian.

Arnold slowed down and said, "the down payment of 12 million is a little more. The down payment of 10 million US dollars and the milestone of 5 million US dollars are acceptable to Jericho."

Although it's a bargain, it's kind of Arnold's way of showing off.

After all, a counter-offer means a bottom line. Although the bottom line is really low.

However, it is also because Yang Rui's offer is low enough that Arnold will bargain and show his kindness.

In the process of new drug development, preclinical research accounts for about 10% to 15% of the total development cost, usually calculated as 13%.

80 In the s, the cost of developing a new drug was more than 100 million US dollars. The cost of developing pure new drugs usually exceeded 200 million US dollars, and a few of them reached 500 million US dollars. According to such cost, the work currently completed by Huarui laboratory should be valued at US $26 million.

However, this is the price of common drugs. As a rare drug, deferonone has a relatively weak profit prospect. Therefore, Yang Rui has a lower price to be attractive.

Seeing that the crowd had no other opinions, Yang Rui nodded and said, "that's it. For the class a no down payment gambling agreement, there are active substances that have passed. No matter how many kinds, the milestone is US $20 million."

"Class B includes a down payment of US $10 million for a gambling agreement, which requires us $10 million regardless of whether there are active substances passing through, but if there are two active substances passing through, the milestone is US $5 million. Three active substances passed, milestone $10 million, and so on. If all the seven active substances pass the clinical phase I, it will increase by US $30 million. "

"No way!"

"It's too high!" All the people at the table objected.

The Japanese even stood up and said, "according to this calculation, category B may have to pay a milestone of US $40 million."

"There are seven kinds of active substances in the first phase of clinical treatment, and it's not much to take 40 million dollars, is it?" What Yang Rui said is very indifferent.

"Too much, too much." The Japanese shook his head and said, "and there are too many seven active substances."

"No one would think there were too many active substances. Moreover, this is only the first phase of clinical treatment. It's no big deal to spend more chips and money. Right. " Yang Rui chuckled twice.

"No, we can't afford to grow so fast." The Japanese shook their heads.

Norwegians and Germans also raised objections, demanding a reduction in the number of milestones.

Although the probability of all the seven active substances passing the clinical stage I is very low, gambling itself is playing probability. Of course, they are not willing to hang a sword on their head.

It is also very difficult and unnecessary to make false in clinical trials.First of all, compared with tens of millions of dollars, it is more important for all seven active substances to pass the clinical phase I trial. No company will fake and cover up an active substance in order to save 5 million dollars after it has passed the clinical trial.

Secondly, clinical trials are a very rigorous scientific research process. Although there is the possibility of cheating, if the agreement is properly signed, the whole process monitoring can be basically achieved. Moreover, many large companies subcontract clinical trials to professional companies. Yang Rui is sure that if all the foreigners are not sitting at this table, the aunt of the neighborhood committee would have been killed.

"It's OK. We just talk." Yang Rui laughed twice.

The owner of the stew shop gave a "Oh", and then told him "keep your voice down", so he went to the tofu stall to report with a teapot.

Yang Rui saw him go far, shook his head, drank a cup of tea, reorganized his thinking, and continued: "how about using similar classification in clinical phase II? The milestone of one pass is US $20 million, with three passes as the middle line, and each more pass will increase by US $10 million.... "

Raymond cunningly said: "the budget of clinical phase II is usually 60 million to 100 million dollars. In this way, if two active substances pass the second clinical phase, we will pay you half of the budget. "

"If there are two active substances that have passed the second phase of clinical trials, it is also because the desferridone active substance synthesized by me is excellent, not good in your clinical trials." Yang Rui simply said: "milestones are used to reward and compensate our work, not to punish."

"According to the maximum amount, seven compounds pass the clinical phase I. If BB is used, we have to pay 52 million..."

"If you think seven compounds will pass the first phase of the clinical trial, you should choose the A-class agreement, which is only $20 million." Yang Rui raised his voice a little.

A few people laughed.

That's what a gambling agreement is like. If you bet wrong, you have to spend more money. If you bet right, you will spend less money.

Raymond shrugged and said, "I just want to talk about possible costs."

"I can't even think of that possibility." Yang Rui laughed. He is sure that there is a high probability that all the seven compounds will pass the clinical phase I, but only four compounds can pass the clinical phase II at most. If we are not lucky, there will be only two or even one.

Clinical stage I and clinical stage II are fundamentally different concepts.

"Comrade, were you just talking about money?" I don't know when the aunt of the neighborhood committee came to Yang Rui.

Yang Rui was surprised to turn around and asked, "do you understand when it comes to money?"

Aunt proud smile, said: "English is not great, our alley, more people understand English."

At the entrance of the alley behind her, there were several red scarves shaking under the street lamp.

Yang Rui praised: "it's powerful."

"It's you who are powerful. What do you sell when you do business with foreigners?" She was smiling.

Yang Rui is not willing to answer, "nothing."

"There must be something, or you'll make people excited. Comrade, which unit are you from Aunt's eyes sharpened.