Chapter 786

Grace's appearance aroused ripples in Huarui laboratory.

There are many foreigners in Yanjing City, and many of them pursue fashion, but it's not easy to see grace, who has beautiful figure and unique fashion taste.

At first glance, it's like the dress of a female soldier in the battlefield. It's a little rough. But if you look at it carefully, the large piece of embroidery on the back of the assault suit and the stitched leather on the leg surface are extremely different.

Wei zhenxue across the window, did not hesitate to comment on the girl with red hair and blue eyes: "in the village, once I saw four colors, I met a leopard."

"You grew up in the compound. When did you live in the village?" Huang Mao knew the root and the bottom of Wei zhenxue, and in a word, he was exposed.

Wei zhenxue coughed and said, "my grandmother lives in the village."

"Your grandmother is from the Coal Management Bureau." Huang Mao sighed, worried about Wei Zhen's ability to learn nonsense.

Wei zhenxue coughed hard again and said, "what's wrong with the Coal Management Bureau? The Coal Management Bureau doesn't like its hometown."

"It's OK to have a hometown, but your hometown is Datong. Is there a leopard in Datong?"

Wei zhenxue's cough lungs are coming out, airway: "pure and I do right, right? How can we not have leopard? There are leopards in our zoo... "

Thinking that it didn't match what he said in front of him, Wei zhenxue coughed again and continued: "our da * ran out with the leopard from the zoo, ran to our village and let me see it, OK?"

"Line is line..."

"What's the problem?"

"Just one."

"Say it." Wei zhenxue is full of anger.

Huang Mao stepped back a little and said, "there are only three colors for the leopard."

"What?"

"Yellow, black and white, didn't you go to the zoo?" Huang Mao said with a smile.

Wei zhenxue hard cough, hard cough: "I was in my grandmother's hometown, saw a leopard running out of the zoo, absolutely four colors, maybe it was stuck with coal ash, yes, it must be coal ash."

"Coal ash is black..." Li Wenqiang asked in a low voice.

Wei zhenxue wanted to cough his lungs out.

In the yard, grace listened to the deafening cough in the room and was worried. She asked, "do any of you have the flu? Or severe pneumonia. "

"No, they're playing games." Duan Bo, who went out to do research work, lied without conscience.

"Learn the sound of pneumonia?" Grace's imagination is very rich: "is it a new project of your laboratory?"

"Of course not. They're just playing. Let's go to the laboratory here... "Duan Bo's two embarrassed people led into the laboratory and introduced their recent work.

Grace put her hand in her trouser pocket and walked around the main laboratory, asking, "who is Yang Rui? I hear he's the leading researcher on deferonone, right? "

"Yes, if Yang Rui's words, he hasn't come today." Duan Bo looked at his watch and said, "he only came here at noon in recent days. Do you want to wait any longer?"

"Of course, I came to see him." Grace said, looking for a place to sit down, said: "you go busy, I wait for Yang Rui to come to see him. By the way, what does he look like? "

"What does it look like..." Duan Bo recalled the description suitable for Yang Rui and replied in written language: "it's long and correct, very correct."

The translator gave grace a good translation.

Grace didn't understand, "what's that?"

"I'll know when I see you." Duan Bo replied.

Two hours later, Yang Rui appeared and grace recognized it at a glance.

"Unexpectedly, there are such men in China." Grace tilts her head and looks at Yang Rui step by step with appreciative eyes.

At this time, Huang Mao, who was in charge of accompanying him, said strangely: "there are all kinds of strange things in the world. There are hundreds of millions of people in China, and all kinds of men."

Grace shook her head and said, "no way."

Huang Mao was surprised: "why?"

"I know all the scholars above the level of biology, not as good as Yang Rui." Grace used the adjective just translated.

The introverted Duan Bo couldn't speak for a moment.

After staring at Yang Rui for a while, grace asked, "it took you three weeks to make 19 derivatives of deferonone?"Yang Rui was also a little shaken by Grace's modeling. He examined between her blue eyes and her high nose and said, "are you the expert that Valentine said?"

"Yes, this is Professor grace Blaine from Cambridge." Valentine suddenly felt a deep sense of crisis. He stood directly between Yang Rui and grace and said, "we can save a little time for greetings to learn about the work of Huarui laboratory on desferridone."

"I think you mean my job." Yang Rui won the credit on himself without hesitation, and what he said was also true. In the process of developing deferonone, he did all the work except for the help of a few experimental dogs.

Valentine laughed twice: "well, your work..."

"May I see your experiment record? Unless it's too confidential. "

"It's classified. You can see what we've screened out." Yang Rui knows that some people will want to know about their work, especially the observation of professionals. His experimental records are complete and can not stand investigation. However, as a drug that has not yet been interviewed, he has no reason to disclose all the information to the other party.

"The filtered part will do." Grace got the bound document and flipped through it quickly.

It is extremely difficult to synthesize a compound, but the molecular formula and synthesis process are extremely simple.

"I want to ask a question." Grace put the paper on the side and said, "why do you choose to make deferonone? In the case of iron chelates, are hbed and DFT more promising

"Maybe, but I think it's a little more realistic." Yang Rui answered with a shrug.

Grice held her chin with her hand, put on a pose, thought for a moment, and said, "if it was me, in order to make the product as soon as possible, I would choose lcl670. Its two phenolic hydroxyl groups and the four n positions on the triazole ring constitute three chelating sites. In terms of the affinity of iron ion, it is not much different from that of defererone, but its lipophilicity is stronger, which ensures the ability to enter cells after oral absorption, It's more realistic than deferoxane

Her string of words and terms instantly made the research atmosphere in the laboratory strong. Several people looked at Yang Rui and wanted to hear his answer.

However, Yang Rui just opened his hand and said, "I'm afraid we will not know the specific performance of lcl670's lipophilicity in human body until clinical trials are conducted. Before that, lcl670 is more difficult to synthesize, is it?"

Grace laughed, looked at Yang Rui with a deep look, and said, "you can synthesize 19 kinds of deferonone compounds in three weeks. It's not easy to synthesize lcl670?"

Yang Rui was stunned. This remark really hit his weakness.

3 Zhou synthesized 19 kinds of deferonone compounds. Even if others say that Yang Rui is fast, Yang Rui doesn't matter. Anyway, I'm strong when I'm fast, and you're stupid when you're slow. There's no need to say such subtext.

But grace's question is very sharp. Since Yang Rui is so good at synthesis, why doesn't he synthesize more difficult but more effective compounds?

In addition, grace has a good vision. Lcl670 will pass the review of the FDA in future generations and become a powerful drug with the trade name of dilarox. Its overall safety and efficacy are better than that of deferonone.

It's hard for Yang Rui to explain this. He can't say that he's very worried about the risk of renal failure caused by dilarox. That's the potential risk of dilarox that was discovered two years after it was listed on the market. Yang Rui didn't even synthesize this drug. How can he make a judgment.

From the perspective of later generations, the latter is still better than the former, but the risk of renal failure is a very strong negative item. It is possible that Novartis carried out clinical trials in those years, or passed the good luck, or the conspiracy theory was covered up. Yang Rui tried his best to avoid these uncertainties.

It took a few years, and finally failed in the third phase of clinical, which is the rhythm of the company's bankruptcy.

Not to mention Huarui's current third-party revenue of $10 million a year, even medium-sized pharmaceutical companies with annual revenue of hundreds of millions of dollars are often unable to bear the failure of clinical phase III.

In the pharmaceutical field where the investment is rising exponentially, most pharmaceutical companies will not even touch the clinical phase II. They are more willing to sell the drugs that have passed the clinical phase I at a good price, and then let the large companies take higher risks and earn more profits.

After thinking about it for a long time, Yang Rui replied: "lcl670 drugs are more complex and cost more. I think that Chinese patients, as well as most patients with dipine, need drugs with lower prices."

"But lcl670 is a better drug." Grace looked Yang Rui in the eye.

"If we can make this kind of expensive drug after many complicated procedures... I will still choose deferoxane. You may not have seen Chinese patients with dipyridamole, and many of them do not use deferoxamine. Even when they need deferoxamine, the high price will stop them." Yang Rui stopped for a moment and said: "in China, in the current China, price is more important than curative effect. Cheap drugs can prolong the life of patients longer than efficient drugs."Yang Rui read and understood enough information from the data collected by the hematologist Yong Xiaodong. At the same time, he also knew the past and present lives of domestic patients. Therefore, his answer was true and realistic.

Grace fell into a long silence.

The lab has been silent for a long time.

Suddenly, grace reaches out her hand, hooks Yang Rui's neck and kisses her heavily.

Fiery red lips, intense and long.

"You are a real scholar, a fighter, and you have a kind heart." Grace said softly after leaving Yang Rui.

But there was still silence, silence and silence.

84 Young people, middle-aged people and old people have never seen this.

Even Comrade Valentine, an Englishman, had straight eyes, like a locust tree cut by thunder.

……