Chapter 781

To give Frankie 300 pig brains, he did not expect that Yang Rui would run to develop new drugs.

If you give Frankie another 600 pig brains, Frankie can't think of it. Yang Rui said that when he developed new drugs, he actually produced active substances.

Of course, active substances can also be regarded as drugs. The process of new drug development is extremely cumbersome. If the work in the laboratory is distributed according to the workload, it may not be half of the total work. What Yang Rui has done is far from one third of the laboratory work.

Nevertheless, Frankie has never heard anything like that from any other company.

Arnold, who had been seduced by him, had never heard anything similar.

In fact, compared with Frankie's habit of shock, Arnold faced the shock with the attitude of an entry-level player. After entering the door of Huarui laboratory, Arnold could not help whispering with Frankie: "it's only a few days?" Didn't you hear that he was doing the work? "

"Of course not. He was still working on coenzyme Q10 catalyst a few days ago. In the past two months, didn't he write a book? It's selling very well. It's a professional bestseller. " Frankie did pay attention to Yang Rui for a long time. If it were not for China's lack of developed media and information industry in Europe and the United States, Frankie would have investigated Yang Rui for a long time.

Arnold was the person in charge of the catalyst contract with Yang Rui two months ago. During his stay in Beijing, he was basically negotiating terms with Japanese and Norwegian companies.

In other words, several multinational enterprises are so slow, they want to see the development of the situation, but also want to lower Yang Rui's offer.

After all, no matter how high the profits of drugs are, there is no reason to give Yang Rui 5% of dry shares in vain, and it is a dividend of global sales. Although coenzyme Q10 is far from being a blockbuster drug, even including a quasi blockbuster drug, it is also a medium-sized product with annual sales of over 100 million in a single company. Besides, what if it becomes a blockbuster?

You can't give Yang Rui 50 million dollars a year. This kind of agreement, the British people think that the egg hurts.

Now, with the sales volume of coenzyme Q10, 2% of the income dividends are quite a lot.

Drugs are products with extremely high profits. The only high price raw material used in semi synthetic coenzyme Q10 is refined solanesol. Under the condition of stable market, jericham can usually get more than 30% profits. 2% of the income dividend is equivalent to 0.6% of the dividend. Based on the current annual sales of coenzyme Q10 of more than 100 million US dollars, The stable income of 600000 US dollars per year is quite a lot, and there is still room for growth.

This is also an excellent condition for biologists. Even a famous American professor, if he signs a contract, can get 600000 US dollars for his guaranteed income from drought and flood. He is happy to jump.

Unfortunately, Yang Rui is not satisfied.

Arnold and his foreign colleagues, also can only tacit understanding of the consumption.

However, this is also the catalyst formula of coenzyme Q10. If we change it to the general idea of interferon, there will be no tacit understanding among different companies, and they will go crazy for a long time.

In order to obtain a drug, the price that large pharmaceutical companies are willing to pay is unimaginable. For example, in order to obtain Lipitor, Pfizer finally acquired Warner Lambert company, its development company, at a price of 82.4 billion US dollars. While the shareholders of the latter made more profits, Pfizer also obtained a total sales volume of 130 billion US dollars from Lipitor. Its peak annual sales volume was 13 billion US dollars, more than the government tax revenue of many countries.

However, the catalyst that can improve the yield of a drug is not an exclusive drug after all.

Arnold also put aside the catalyst, looked at Yang Rui's experimental records, and asked, "what kind of cooperation do you want?"

"This is the first time that we have developed drugs, so we need any cooperation." Yang Rui shrugged and said, "it's mainly about information. If you want, I can pay a consulting fee."

"Consultation fee? How much is it? "

"10000 dollars for air tickets and hotels."

"Ten thousand dollars is not enough for an investigator," Arnold said

"I know." Yang Rui smiles.

Arnold's face changed: "do you want Jericho to work for nothing?"

"It's not bad for you to send two people in and keep abreast of our progress, right?"

"That's impossible." Arnold was smiling. He wanted to say that it was almost the same when you gave the formula of coenzyme Q10 catalyst to Jericho, but it was not the right time to mention it, so Arnold put up with it.

Yang Rui shrugged his shoulders and said, "then don't cooperate. I invite you to be observers. If you want to say it, you can say it. If you don't want to say it, it's in your favor, right?""No contract?" Arnold's mind is moving. It's really no harm to understand the situation unilaterally.

Yang Rui shook his head: "at least sign a confidentiality contract."

"What do you observe after signing the contract? Observers who cannot report... "

"You just report the results, not to mention the process." Desferridone, which has just reached the stage of synthesis, will not reveal much as long as it is not seen by special pharmacists or photographed.

Arnold because of the relationship between Yang Rui, really very curious, can not help but hesitated.

"Why don't you be an observer for one day first, and then have a look." Yang Rui then asked the company lawyer waiting in the laboratory to come and sign the confidentiality agreement for Arnold.

Arnold declined, but looked at the agreement carefully and signed it.

"Old Wei, show it to the English gentlemen." Yang Rui gave them a white coat and led them into the laboratory to introduce deferonone.

It is impossible for Yang Rui to make a normal offer to Jericho, because he can't start. The medical industry is an industry chain sound to abnormal industry, every kind of work has a price, and are exorbitant.

For example, the most annoying clinical trials, many people think that clinical trials are drug research carried out by pharmaceutical companies in combination with hospitals or independently. But in fact, there have been clinical trial companies in Europe and the United States long ago. They are specialized in providing clinical trial services for various pharmaceutical companies, with annual sales of more than 1 billion.

As for professional consulting companies, they are usually deceiving people, but the fees are even more exorbitant. The million dollar price is just the beginning.

Now, for preclinical research, pharmaceutical companies often spend tens of millions or even hundreds of millions of dollars, half of which is spent outside the laboratory, and Yang Rui can't afford it.

His income mainly comes from the dividends of Jielikang, and his expenses are mainly used for lawyer's fees. The former can be slightly more than the latter, which is enough for Yang Rui to carry out some experiments that are difficult to carry out in China, such as the synthesis of deferonone. However, after the synthesis, Yang Rui can not afford to spend any part of the money, let alone outsource it, Or outsourcing to jerichon.

In fact, many domestic laboratories of later generations do outsourcing work from abroad, such as animal experiments, determination of active ingredients, etc., which is complicated and quite profitable. But in essence, it is similar to Foxconn, and the profits are squeezed by reducing costs. The reduced costs are usually the students of scientific researchers or tutors, Or just graduated little masters and doctors.

In the long pharmaceutical industry chain, the higher the upper level, the higher the capital needed, the greater the risk taken, and the more profits obtained.

Domestic companies and laboratories are small and weak, so they can't do original drugs without outsourcing.

Even the research and development of original drugs in the 1980s can not be undertaken by Chinese laboratories.

In this respect, Yang Rui has a desire from Jericho.

It's not comfortable to ask for help, but you are inferior. When it's time to bow, you have to bow.

Medicine is not art. Art can advocate strong points, pretend grievances, be indignant, be angry, take it for granted and ignore it.

But those who make medicine are not as skilled as others, and they don't bow down. They just waste their time and energy, their accumulation and the trust of the people around them.

The time, energy, accumulation and trust are often measured in ten years.

It takes ten years to waste a single scholar's essence. Only in order to keep his head down, only bureaucratic artists and animals can do that.

Yang Rui is not one of them.

As a novice in the pharmaceutical field, Yang Rui has little experience. Unlike writing papers or monographs, Yang Rui's contact with pharmaceutical companies is limited to the laboratory and production.

How to develop a kind of medicine is basically out of his educational direction.

84 In China, no one understood this.

Domestic pharmaceutical companies may know how to pass the domestic drug audit, but if they want to pass the audit of drug regulatory agencies in the United States, the United Kingdom and France, which are big drug consuming countries, Yang Rui must seek the help of Jericho.

This is not only for the safety of the drug itself, but also for desferridone to achieve the purpose of cheap control of thalassemia.

The synthesis of an active substance of deferrone is only the first step in the long march. Next, Yang Rui needs to synthesize more deferrone active substances, so as to find the most appropriate deferrone molecule. The same core molecule has different side chains, which may lead to different properties and more toxicity.

In order to complete the rest, the cost may be millions of dollars, tens of millions of dollars, or even hundreds of millions of dollars.Whether or not Yang Rui can afford the cost, he has no reason to.

The responsibility of pharmaceutical enterprises is to manufacture drugs, not charity, not charity. Deferonone must be able to obtain more than the cost of sales, in order to continue research and development and production line, Huarui can continue to develop.

And to do this, we must have foreign patients to share the cost.

"Huang, follow Arnold and Mr. Frankie and show him our achievements. Lao Wei, let's continue. " Yang Rui rubbed his hands and said in English: "the fifth experiment of synthesis of deferonone, start."

……