Chapter 778

Yang Rui quickly set up a drug research group in Huarui laboratory, and selected Wei zhenxue to cooperate with him, plus two scientific research teams, even if the grass-roots team of desferridone was set up.

Including inside Huarui laboratory, everyone is not optimistic about Yang Rui.

If he had not accumulated great prestige for more than a year, the colleagues in Huarui laboratory would have opposed Yang Rui's decision, just like Xu Zhengping.

In this period of time, opposition is the normal response.

Pharmaceutical research itself is a very professional field. In the original pharmaceutical companies, researchers who spend half their life on a kind of drug basically exist as gods in the field of subdivision and specialization. After Reagan's act, universities and research institutions at all levels, some experts and scholars from academia to industry, greatly enriched this field, and also raised the threshold of pharmaceutical research infinitely high.

Not to mention the team of Caotai, it is to spend hundreds of millions to form a team, which is not a dream team in the field of drug research.

Scholars in the academic circle naturally despise researchers in the industrial field, but it's true that the Nobel Prize winners in the industrial field are not much less than those in the academic field. Especially from the 1980s to the 1990s, it was popular for scholars who won the Nobel Prize to change jobs, because large pharmaceutical companies paid too much, and they often quoted millions of dollars, Besides, those professors who have won almost lifetime achievement awards at the age of 40 and 50 are really lack of pursuit in the academic circle, and many people plunge into the ocean of industry and even business.

Super pharmaceutical companies such as Jericho have never been afraid of the challenge of small pharmaceutical companies. Their biggest magic weapon is acquisition. They can buy out all promising small pharmaceutical companies at a price of US $35 million or even US $100 million. Even if they can't, they will buy out the products of small pharmaceutical companies directly.

For example, if Yang Rui didn't intervene in the PCR technology of west company, it would be sold at a price of 300 million US dollars. Several Nobel Prize winners in west company also used this money to improve their lives and work in other companies

In a word, modern pharmaceutical enterprises have the highest technical requirements, In contrast, the industrial sector outside the pharmaceutical companies has been basically separated from the academic sector. For example, the experts in the academic field who study machinery are basically trapped in the physical world. The metallurgical industry is making materials, the material industry is making micro crystals all day long, and the crystal industry is checking the hygiene, Computer professors don't know what to do for a long time

Only the R & D of pharmaceutical enterprises can use Nobel Prize scholars from theory to production. In other words, the world's top technology can be directly used in terminal products.

Naturally, this process is extremely complicated. Sometimes it even depends on luck. For example, deferrone is an iron chelating agent. However, no research group of any pharmaceutical company ever thought of saying "I'll find an iron chelating agent" or "invent an iron chelating agent". He can only wait for an iron chelating agent to be discovered, Then consider how to make it into medicine.

Only after the discovery of desferridone can desferridone be used as a drug.

This is also the self-confidence of Yang Rui that no one else in the pharmaceutical sector understands. However, Wei zhenxue doesn't care at all. As long as he has experiments to do, the higher the experiment, the more he likes it.

When they went back to Xibao middle school, no matter what other people said or did, they were just doing their own experiments.

"The fourth experiment of deferrone, the direct reaction of 3-carboxy-2-methyl-4-pyranone with methylamine..." Yang Rui made a good record of the experiment, and immediately began the experiment.

Wei zhenxue helped and said, "you can't do it like this. If you can do it by direct reaction, people don't synthesize iron ketones long ago."

"It's because the predecessors haven't tried too much. When hider first discovered deferrone, he only did research on iron chelation, and did not carefully study the synthesis of deferrone. " Yang Rui shrugged his shoulders and said, "hider uses the method of predecessors. The yield is too low."

"Far from being too low, I don't think he knows how to synthesize compounds at all." Wei zhenxue said with a laugh: "the yield of less than 1% is not pure enough. I don't know how many people will be killed if it is made into medicine. How about the name hider

Yang Rui did not say a word, still looking at the test bench.

Wei zhenxue boasted: "I don't say it. I was born in chemistry. When I was working in coal chemistry, I also published many papers. I don't know the level of hider. The method he used is really not good. The one you use is even worse. You'd better listen to me. Let's start with the protection of carboxyl group, find a way to methylation, and then deprotection. It's estimated that we can get deferonone.... ""It's also a way." Yang Rui did not comment.

"I think it's more reliable." Others will not talk to Yang Rui like this now. Only Wei zhenxue has not changed his mind for many years.

Yang Rui said with a smile, "it's true that it's more reliable, but it's also more troublesome. Let's first consider whether simple methods can be done or not, and then consider complex methods."

"You said the opposite."

"I can't manage so much. Let's do this first." Yang Rui replied casually.

The method Yang Rui uses now is a chemical synthesis method invented in 1994, which is the cheapest one.

Hider Needless to say, it's a substitute in the 1960s, which can't be used in industrial production. As for the method proposed by Wei zhenxue, if it is modified a few more places, there is a chance to synthesize iron ketone, but Yang Rui is not prepared to use it.

Because he only needs one way to produce deferonone. As a researcher who is not familiar with chemical synthesis, it's normal for him to get a simple and convenient chemical synthesis method. If he gets more than one, it's impossible.

Therefore, Yang Rui was in place once and for all. He simply used methylamine for direct reaction.

However, according to the normal chemical thinking, a direct reaction such as formation has always been difficult. In the words of scholars, it is unreliable.

Generally speaking, people prefer to find a simple way to produce it first, and then gradually improve it. Just like coenzyme Q10, Yang Rui has transformed it for three times, but it has not been in place yet. Jielikang is also very satisfied.

Unfortunately, deferonone is not as profitable as coenzyme Q10. Yang Rui is more inclined to establish a pharmaceutical company through this work. Therefore, his work focus is on clinical trials and application process rather than pharmaceutical process.

Therefore, after making several wrong experiments, Yang Rui couldn't bear it. He didn't bother to upgrade step by step. He took out the technology that a certain scholar developed 10 years later and let those gases and liquids wander over his experimental table.

Wei zhenxue shook his head repeatedly and said: "Yang Rui, it's not me who said that you are indeed a gifted biologist. I've seen the strongest one, and Peking University probably can't find one more powerful than you. But biology is different from chemistry. You are a biologist. No matter how talented you are, you are good at biology. But I am a chemist. Synthetic chemistry should listen to me, right

"Do it first..." Yang Rui perfunctorily tells Wei zhenxue.

"If you don't listen to me, why do you come to me?" Wei zhenxue said, "if you don't listen to me, I'll go back."

With that, Wei zhenxue was about to leave.

Yang Rui was stunned and said, "I'm looking for you to be my assistant. I'm not asking you to be my uncle."

"Is that so?" Wei zhenxue's steps to leave have been suspended.

"Of course."

"Don't you want me to help you with the synthesis of deferonone?"

"To be an assistant is to help."

"Well... I thought you asked me to take charge of the work." Wei zhenxue turned his ankle and went back to the test bench, saying, "then I'll be an assistant."

"It is." Yang Rui can't laugh or cry. He hasn't experienced Wei zhenxue's second thought for some time. At first, he doesn't adapt to it.

Wei zhenxue never changed. He looked at Yang Rui's experimental record again. The more he looked at it, the more he shook his head. He said, "even if you don't let me take charge of the work, when I'm an assistant, I'll say that you can't do it like this!"

"Wait and see." Yang Rui did it several times before when he knew he couldn't do it, so he was familiar with the equipment and test methods. This time, he used simple direct synthesis, and he was more confident.

Wei zhenxue was also overwhelmed by his confidence. He vowed: "I'll wait and see. If you can directly synthesize iron ketone with methylamine, I'll twist my head off and kick it for you."

Yang Rui couldn't help laughing.

Huang Mao, Tu Xian, Li Wenqiang and others in the laboratory were curious to pass by when they heard about the bet.

Wei zhenxue inexplicably felt the chill of his back neck.

……