Chapter 776

At the end of the meeting, Xu Zhengping understood Yang Rui's idea and said in dismay, "it's really wrong for us to do ferroketone."

There are people who do biology who do medicine, but this does not mean that any scholar who does biology can do medicine research, let alone do what medicine he does.

Yang Rui's ion channel laboratory, normally speaking, belongs to the foundation of basic biology. It has been based on the ion channel of cells. It is almost the lowest bioactive substance that human beings can contact at present. What else is the basis.

In a few years, with the rise of targeted drugs, the biologists in ion channel laboratories will really have something suitable for drug research, so it's OK to move to the industry to make some money.

But now, the research of ion channel laboratory is far ahead of drug research. In addition, the scholars in the laboratory are not willing to give up their position to do the work of industry. As for Xu Zhengping himself, he gets almost the same salary anyway. Why don't you stay in the promising Laboratory of Peking University, do promising basic research, and brush up papers? If you slow down, the people behind will catch up, and your previous efforts will be in vain. When you turn around two or three years later, you once occupied the leading position, Maybe it's all in the rear.

To choose to do scientific research is to choose a lifetime of competition. A little bit of ideal scientific research workers, starting from grade three, are basically in the state of annual college entrance examination. Those who can't stick to it will be eliminated naturally. In any case, a scientific research leader only needs a few top people in the end, and the rest who can be filled with scientific research dogs will be filled with scientific research dogs, Just a few more scientific apes.

Only a guy like Yang Rui can think about doing something else.

However, Yang Rui also understood Xu Zhengping's idea and said, "let's go to the doctor who spoke before and see what the specific situation is."

He thought that if the ion channel laboratory could not make drugs, it would be done by Huarui laboratory.

It's not a profitable project, but in the end, it should be able to make money. After all, Yang Rui doesn't have to worry about the most time-consuming R & D process, and he doesn't have to worry about not producing results. These parts are the ones with the greatest risk. As for clinical trials, it's right to spend energy and time, but the main thing is the trouble. The level of drugs is passable, and clinical trials are always passable. There are so many countries in the world, and it's not necessarily necessary to sell them all over the world.

In fact, Yang Rui doesn't care if he doesn't make money.

The ultimate purpose of his establishment of Huarui laboratory is for freedom, not only the simple financial freedom of personal enjoyment, but also the pursuit of ideal financial freedom.

Yang Rui's ideal is to do whatever experiment he wants, and do whatever research he wants. Silver chloride, platinum rods, throwing a piece of pure sodium to watch the explosion, and making tea with four nines

In fact, it doesn't need any explanation to rashly pull Huarui laboratory to make a drug that doesn't make much money. It's just money and willfulness.

"I want to see the patient." Yang Rui looked around and said, "it's just in the hospital. Ask if you can have a look on the spot."

"All right." Xu Zhengping didn't object. As the deputy director of ion channel laboratory, he wanted to support Yang Rui. He turned to Wang Sisheng and said, "Xiao Wang, do you know the doctor who just spoke?"

Wang Sisheng said, "how can I know you?" he turned around and said with a smile, "I'll ask."

In a moment, Wang Sisheng asked someone to come over and said, "it happened to be the doctor of the Union Medical College Hospital. His name is Yong Xiaodong. I reported the name of director Yang, and they immediately agreed. Now I'm in the inpatient department. I'll send someone to pick us up later. "

After a total delay of less than half an hour, Yang Rui met Yong Xiaodong on the first floor of a building in the inpatient department.

"Director Yang, director Xu, Comrade Wang..." Yong Xiaodong warmly shook hands with the three people and called the three scientific research Wang who followed him. As he walked along, he introduced: "my work now focuses on thalassemia. I'm very glad that you are interested in understanding it. This disease is too little to understand."

Soon, Yang Rui knew why people didn't want to know.

It's too bad.

If the hair loss of cancer patients after chemotherapy is a change in appearance, then severe thalassemia can be said to be a change in appearance.

The deformity of bone due to compensatory hyperplasia has transformed the patient beyond recognition. Most patients with severe diseases are children

Even the oldest Xu Zhengping can't see the face, abdomen, legs and arms of a child who is the most senior in primary school, Can't help asking: "Why are they all so small?""Severe thalassemia is a disease of premature death." Yong Xiaodong whispered.

The implication is that the old are dead.

Xu Zhengping shook his head and said, "I remember you said in your report today that the average age is between 15 and 20 years old. Here are all primary school students...."

In fact, it's not only primary school students, most of them are below the third grade of primary school, and many of them are kindergarten children, I don't even understand what happened

"Generally, those sent to our hospital are those whose parents still have a glimmer of hope. Those who can't be cured by the age of nine or ten usually go home." Yong Xiaodong said in a low voice: "there are not many people suffering from thalassemia in the north, mainly in the south, especially in Yunnan and Guizhou provinces. There are more gene carriers and patients with thalassemia. When they come to the capital, they will spend a lot of money. If there is no obvious improvement, most of them will choose the hospital at home, or some of them will not be treated. "

"Didn't you insist on treatment?"

Yong Xiaodong said with a bitter smile: "we can't talk about treatment at all now. Besides blood transfusion and iron amine, there is no other treatment plan. And it costs a lot. "

It's not just expensive. Severe thalassemia requires long-term blood transfusion and infusion. When you are older and your hemoglobin drops, you have to have regular blood transfusion. It takes a long time, and the dosage is large. Combined with the treatment of complications, it can be said that it costs a lot of money every day.

Yang Rui can see his decadent father, sad mother, distressed parents and numb children when he looks around.

Less than half a month, at most once a month, blood transfusion, iron removal injections, and appearance changes are not enough to make children feel the beauty of life.

Even if we develop iron ketone, I'm afraid we can't talk about a better life.

But the pressure will be much less.

Yang Rui thought about it and asked, "if we develop an oral iron remover, will it help?"

Yong Xiaodong asked: "does a pharmaceutical factory produce oral iron remover?"

"Not yet. I want to know about it first."

"If there is an oral iron remover, it will certainly help. At least these families can stick to it for a few more years." Yong Xiao said to the East: "although in the end, it is still the same result, but it should be different."

Being a doctor for a long time is usually not too emotional, but in the face of a group, feelings will be enriched.

Looking at his expression, Yang Rui could not help comforting: "although the final results are the same, it is also important that the process is different. We are not God, we can't change the world, but I think there is a big difference between a child who died early at the age of 15 or 16 and dying at the age of 30. At least we can see the world, and the first ten years of life can be easier. "

"And there are intermediate thalassemia patients, and they can get more changes."

Yang Rui nodded and introduced the hydroxypyridinones studied by hider, saying: "I don't know much about deferrones, but as far as we know, deferrones are electrically neutral, lipophilic and low molecular weight, which means that..."

"It can be absorbed in the gastrointestinal tract!" Yong Xiaodong responded immediately.

Yang Rui nodded: "and it can penetrate the tissue cell membrane. Now we don't know how it will behave in cells, but from a better direction, it should be able to chelate the iron atoms in cells."

Normal infants should pay attention to iron supplement when they eat milk powder, but for children with thalassemia, every reduction of iron means prolonging their life span for a period of time and improving their quality of life.

Yong Xiaodong quickly walked two steps excitedly, but after a while, he stopped and said with chagrin, "it's a pity that no pharmaceutical factory produces the oral iron remover you said. Even if the basic conditions are available, foreign pharmaceutical factories are still reluctant to develop it."

The reason why we only talk about foreign pharmaceutical companies is that Chinese pharmaceutical companies have no ability to produce original drugs.

Pharmaceutical companies in the world are divided into two categories. One is original pharmaceutical companies, including well-known Johnson & Johnson, Pfizer, Bayer, or jerichon.

Besides the original drug companies, there are also professional generic drug companies.

Generic drug company is a company that imitates drugs after the patent of original drug company is invalid. For example, Viagra is owned by Pfizer, but when the patent of Viagra expires, Kingo can be sold, and it is not necessarily cheap. On the contrary, it saves the drug development process with unpredictable risks. The extremely difficult clinical trials are equivalent to reducing the cost of hundreds of millions of dollars, and saving the average 15 years of research and development time.

In Europe and the United States, the number of generic drug companies is dozens of times that of original drug companies, and the scale and strength of many companies can not be underestimated - if you want to copy others, you have to have a certain level.Some generic pharmaceutical companies are also large-scale, such as Israel's DIWA pharmaceutical, Germany's Sanders, the United States of America's mylan, are big pharmaceutical companies with annual sales of billions or even tens of billions.

In China, the original drug companies basically do not exist, that is, the scale of generic drug companies is very small. Except for some popular products in common use, the drugs produced in the 1960s abroad can not be imitated in China at present.

In this case, it is not reliable to expect domestic pharmaceutical enterprises.

Yang Rui patted Yong Xiaodong and said, "I'll find a way."

"Can you think of a way?" Yong Xiaodong obviously didn't believe it.

Wang Sisheng couldn't help saying, "director Yang has a good relationship with Jericho in the UK."

Yong Xiaodong's lips moved, but he couldn't help saying, "it's useless. British people can't tolerate thalassemia."

"It's not the British, we're on our own." Yang Rui's eyes look at the bedside. The child on the bedside is pitifully lying in the infusion. He doesn't know whether he is asleep or awake. His chest and legs are bony and his stomach is high. His mother sitting on the side lowers her head. When the doctor comes, he just looks up and lowers it heavily.

Xu Zhengping took a look at Yang Rui's eyes, took a cold breath, and hurriedly said, "director Yang, this matter should be considered in the long run."

"I know."

"Director Yang, Yang Rui, medicine is the research of biochemistry. Let's start from scratch. How can we make it in time?"

"It must be done as soon as possible, of course." Yang Rui takes back his eyes and sighs in his heart, but he secretly decides to be his own original drug company.

Even if you don't make money, even if you lose money, you should build this pharmaceutical company first.

No scientific research product is ever produced without input.

Biological and pharmaceutical industries are the typical ones.

China also needs to have its own original drug enterprise.

If it's industrial products and agricultural products, it doesn't matter whether they have their own factories or not. International division of labor and cooperation, you produce precision machine tools, I produce refrigerators. I need your precision machine tools, and you can't use refrigerators.

Agricultural products, in fact, are no big deal. The U.S. government will not deliberately make the Chinese hungry, and there is no need to do so. It's just that the price is a little higher and the quality is poor.

But the drugs are really different.

As Yong Xiaodong said, the British can not tolerate thalassemia. Therefore, it is very difficult for British pharmaceutical companies to have the impulse to make thalassemia drugs. The reason why it is difficult is that India is the traditional market of the United Kingdom, while South Asia, where India is located, is the critical area of thalassemia. Therefore, the Indian company finally came into being, He insisted on making desferridone.

Germany, France, Italy, Spain, Norway and Denmark, which are also European countries, don't even need to add the adjective "very difficult". It's impossible for them to take medicine for thalassemia, because there are no thalassemia patients in their country at all. Instead of spending more than ten years to study the medicine, It's better to choose a common disease in our own country to conquer.

In the final analysis, the common genetic diseases of Chinese people need to be tackled by their own pharmaceutical companies.

This will also be the grim reality faced by all countries and nations in the post gene era.

If you don't invest in scientific research, you don't think there's any reference in the cottage.

If they are not willing to invest, people from other countries may donate sympathetically, but they will never donate to a top-notch scientific research team for 15 years, which is like a bottomless hole in research funding.

……