Chapter 467

Hughes Medical Research Institute, one of the most famous non-profit medical research institutes in the United States, has become an "angel team" Research Institute for VFV specific drugs under the coordination of who.

Qiu wants to lead the group towards the meeting room.

Qiu Xiang now has a report on the study of VFV antibody, but the faces of all the people are not very happy.

The antibody in the patient's serum or body fluid is the most common way to treat virus infection. During this period of time, their team found that the antibody in the patient's serum was too weak to remove the VFV virus at all.

And they can not find patients in recovery period. VFV virus is too toxic. The antibody produced by the immune system of human body can not "kill" the virus at all.

As a result, their research on specific drugs was at a loss.

After discussion, the team decided to try animal immune serum, find 8 kinds of animals to experiment, let the animals infected with the virus, but soon found that even after the immunization of bovine serum, there is no obvious effect on the treatment of VFV.

During this period, I experimented every day, trying hundreds of possible ways.

Try all the possible conjectures they discussed, and finally find that the most successful one is monoclonal antibody.

In order to speed up the research, the 72 person team is divided into eight groups, four groups are responsible for finding other therapeutic drugs, the other four groups are responsible for testing the 16 monoclonal antibodies that have been developed. The team led by Qiu Xiang is one of them.

At the time of the test, the four groups all used 1000 times LD50 (half lethal dose) to infect the experimental mice.

Within 24 hours after exposure, mice were injected with monoclonal antibodies, 16 monoclonal antibodies in four groups, 11 of which were effective; 5 of which were still effective in 48 hours; and only two of them were effective in 72 hours.

It's an antibody from the first group he led, and an antibody from the third group led by Judson, a British medical scientist.

After finding two kinds of antibodies, they began to experiment with rabbits again, 24 hours later, both of them were effective; 48 hours later, the ability of monoclonal antibodies began to show obvious differences, many of them lost their activity, and the effect of antibodies became weaker and weaker after a long time.

The incubation period of VFV virus is far longer than this time. Such antibodies can not be used for treatment at all, and the research stops again.

Finally, after the discussion, we decided to use the "cocktail" method of Ebor specific drug research, using the best four monoclonal antibodies to mix, using a virus that can produce human interferon as the adjuvant of "cocktail" antibody, so that the "cocktail" can play a role 72 hours after exposure.

The cocktail potion was named ag72 by them.

Now, the ag72 test results are in the hands of Qiu Xiang.

Looking at the report in hand, he was not happy because the result was different from what they imagined.

When Qiu Xiang and Judson enter the conference room, they feel dozens of eyes falling on them. Many researchers on the field don't look very good. Since the formation of the 72 person team, their research has made some progress, but the progress is not great. Now I hope all of them are on the reports in the hands of Qiu Xiang and Jason.

"Come on." Qiu wants to pass the report to Jason.

"You come." Judson shook his head and didn't reach for it.

Qiu thought he could not help nodding. When all the people were seated, he asked his assistant to send the report to every researcher on the field, and walked up to the podium.

"The monoclonal antibody test results are out, which is different from our prediction. We tested the effect of ag72 with two rhesus monkeys. On the fourth day of infection, the monkeys developed symptoms and were given ag72 as planned. But unfortunately, the virus in monkeys has not disappeared, and VFV has not been cured. " Qiu Xiang's voice is heavy.

There was a sigh in the conference room. Many experts shook their heads and frowned.

Monoclonal antibody is the most promising direction in a short period of time. If monoclonal antibody fails, the emergence of specific drugs will last longer.

Now the number of people infected with VFV virus has reached more than 26000 worldwide, and the number is refreshing every day. The death toll has also soared to 2378, and there is no cure. If the treatment doesn't come out, it means more and more people will die.

"But there is not so good news."

All of them were in a moment's energy, and stood up to wait for Qiu's answer.

"The rhesus monkeys injected with ag72 did not get worse within one week. Ag72 can not cure VFV, but it can inhibit VFV metabolism and control the further deterioration of VFV. This achievement, can give the illness to strive for more treatment time

Many people applauded excitedly and cried with joy. At this time, any little good news is exciting good news.

Angel team made a breakthrough in VFV specific drugs and successfully developed monoclonal antibody agents to inhibit the deterioration of VFV.When the news was released, it seemed to spread around the world as if it were crazy and aroused the excitement of the whole people.

Now is the most serious period of VFV virus, is in the global panic, the biological virus almost reached the critical point of total out of control. At this time, the good news from the 72 member team is undoubtedly the most exciting time.

The victory in the biological war has already dawned.

While cheering for the results of the group of 72, there was the same happy event in another corner.

Institute of river microbiology.

Xu Minsheng has a rare smile on his face.

After Jianghe company and lanhong pharmaceutical were merged by marching ant group, Jianghe pharmaceutical was formed again. He became one of the team leaders of Jianghe pharmaceutical pharmaceutical development, responsible for the development of tumor vaccine.

At present, Jianghe pharmaceutical headquarters is the main Institute of microbial medicine of starfish company, and the main drugs of starfish company are all developed from here.

Some time ago, Chen Mo contacted them and told them about a research direction. He also gave them some information, so that the team of his research institute could make a drug related to the information. The drug might reduce the activity of VFV and be helpful for the treatment of VFV.

Now it's the most terrible time for VFV virus to ravage. With Chen Mo's order, the entire research institute team immediately called together personnel to start the development of drugs.

The team concentrated the efforts of the whole institute's elites, absorbed the materials provided by Chen Mo, and finally made progress in the research.

During this period, Chen Mo was contacted several times and asked some questions about the research direction. After several major breakthroughs, he finally completed the required medicine according to Chen Mo's meaning.

They gave the developed medicine the name HX3.

Now, after adding HX3, the activity of VFV in culture dish decreased obviously in 24 hours, and the drug has reached the requirement of silence.

"It worked." Xu Minsheng shows a rare smile.

"It worked." Several researchers around nodded and breathed deeply.

"You will sort out the report and give it to the boss. I'll ask the boss what to do with HX3. " With that, Xu Minsheng turns and leaves the lab.